| Gene Symbol |
BAK1
|
| Entrez Gene |
578
|
| Alt Symbol |
BAK, BAK-LIKE, BCL2L7, CDN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BCL2-antagonist/killer 1
|
| Other Description |
BCL2-like 7 protein|apoptosis regulator BAK|bcl-2 homologous antagonist/killer|bcl-2-like protein 7|bcl2-L-7|pro-apoptotic protein BAK
|
| Swissprots |
Q16611 C0H5Y7 Q6I9T6 Q92533
|
| Accessions |
AAO74828 BAA13606 EAX03740 EAX03741 EAX03742 Q16611 AF520590 AAM74949 AK091807 BAG52419 AK292093 BAF84782 AK293547 BAG57025 AK303422 BAG64474 BC004431 AAH04431 BC032789 BC110337 AAI10338 BM855203 CB142221 CR457419 CAG33700 CR627020 CAI46254 DQ892527 ABM83453 DQ895739 ABM86665 U16811 AAA74466 U23765 AAA93066 X84213 CAA58997 XM_011514779 XP_011513081 XM_011514780 XP_011513082 NM_001188 NP_001179
|
| Function |
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. {ECO:0000269|PubMed:17157251, ECO:0000269|PubMed:8521816}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
|
| Top Pathways |
Protein processing in endoplasmic reticulum, Viral carcinogenesis, MicroRNAs in cancer
|
![Western Blot: Bak Overexpression Lysate (Adult Normal) [NBL1-07909] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Bak.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6145_Bak%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07909-img0002.jpg)