| Gene Symbol |
APOO
|
| Entrez Gene |
79135
|
| Alt Symbol |
FAM121B, My025
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein O
|
| Other Description |
brain my025|family with sequence similarity 121B
|
| Swissprots |
B2R4K9 Q9BUR5 Q9H3J9
|
| Accessions |
EAW99001 EAW99002 EAW99003 EAW99004 Q9BUR5 AA410995 AF061264 AAG43139 AK311865 BAG34806 AY359114 AAQ89472 BC002333 AAH02333 BC010102 AAH10102 BC016814 AAH16814 BX099786 DB466960 EL951748 XM_011545584 XP_011543886 XM_011545585 XP_011543887 XM_011545586 XP_011543888 XM_011545587 XP_011543889 NM_024122 NP_077027 NR_026545
|
| Function |
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation. {ECO:0000269|PubMed:16956892}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:16956892}.
|
| Tissue Specificity |
Expressed in all tissues examined. Up- regulated in diabetic heart. {ECO:0000269|PubMed:16956892}.
|
![Western Blot: APOO Overexpression Lysate (Adult Normal) [NBL1-07630] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APOO.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3948_APOO%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07630-img0002.jpg)