Gene Symbol | APOO |
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Entrez Gene | 79135 |
Alt Symbol | FAM121B, My025 |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein O |
Other Description | brain my025|family with sequence similarity 121B |
Swissprots | B2R4K9 Q9BUR5 Q9H3J9 |
Accessions | EAW99001 EAW99002 EAW99003 EAW99004 Q9BUR5 AA410995 AF061264 AAG43139 AK311865 BAG34806 AY359114 AAQ89472 BC002333 AAH02333 BC010102 AAH10102 BC016814 AAH16814 BX099786 DB466960 EL951748 XM_011545584 XP_011543886 XM_011545585 XP_011543887 XM_011545586 XP_011543888 XM_011545587 XP_011543889 NM_024122 NP_077027 NR_026545 |
Function | Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation. {ECO:0000269|PubMed:16956892}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:16956892}. |
Tissue Specificity | Expressed in all tissues examined. Up- regulated in diabetic heart. {ECO:0000269|PubMed:16956892}. |
apoO CRISPR/Cas9 KO Plasmid (h) - sc-413137 from Santa Cruz Biotechnology
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apoO HDR Plasmid (h) - sc-413137-HDR from Santa Cruz Biotechnology
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apoO Double Nickase Plasmid (h) - sc-413137-NIC from Santa Cruz Biotechnology
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apoO Double Nickase Plasmid (h2) - sc-413137-NIC-2 from Santa Cruz Biotechnology
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apoO CRISPR Activation Plasmid (h) - sc-413137-ACT from Santa Cruz Biotechnology
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apoO CRISPR Activation Plasmid (h2) - sc-413137-ACT-2 from Santa Cruz Biotechnology
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apoO Lentiviral Activation Particles (h) - sc-413137-LAC from Santa Cruz Biotechnology
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apoO Lentiviral Activation Particles (h2) - sc-413137-LAC-2 from Santa Cruz Biotechnology
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apoO siRNA (h) - sc-90923 from Santa Cruz Biotechnology
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apoO shRNA Plasmid (h) - sc-90923-SH from Santa Cruz Biotechnology
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apoO shRNA (h) Lentiviral Particles - sc-90923-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3357 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02461 from Sigma-Aldrich
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APOO siRNA (Human) - CRJ2320 from Cohesion Biosciences
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APOO - MBS8213768 from MyBioSource
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shRNA set against Human APOO (NM_024122.4) - SHH238702 from Creative biogene
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APOO shRNA Plasmid (Human) - CHJ2320 from Cohesion Biosciences
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APOO miRNA 3'UTR clone - MiUTR3H-02926 from Creative biogene
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