| Gene Symbol |
SLC26A4
|
| Entrez Gene |
5172
|
| Alt Symbol |
DFNB4, EVA, PDS, TDH2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 26 (anion exchanger), member 4
|
| Other Description |
pendrin|sodium-independent chloride/iodide transporter
|
| Swissprots |
B7Z266 O43170 O43511
|
| Accessions |
AAB88773 AAS02011 EAW83414 O43511 AF030880 AAC51873 AK294388 BAH11752 AK298543 BAH12811 AK300604 BAH13312 BC148375 AAI48376 BC153002 AAI53003 XM_005250425 XP_005250482 XM_006716025 XP_006716088 NM_000441 NP_000432
|
| Function |
Sodium-independent transporter of chloride and iodide. {ECO:0000269|PubMed:10192399}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. {ECO:0000250}.
|
| Tissue Specificity |
High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.
|
| Top Pathways |
Thyroid hormone synthesis
|