Gene Symbol | SLC26A4 |
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Entrez Gene | 5172 |
Alt Symbol | DFNB4, EVA, PDS, TDH2B |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 26 (anion exchanger), member 4 |
Other Description | pendrin|sodium-independent chloride/iodide transporter |
Swissprots | B7Z266 O43170 O43511 |
Accessions | AAB88773 AAS02011 EAW83414 O43511 AF030880 AAC51873 AK294388 BAH11752 AK298543 BAH12811 AK300604 BAH13312 BC148375 AAI48376 BC153002 AAI53003 XM_005250425 XP_005250482 XM_006716025 XP_006716088 NM_000441 NP_000432 |
Function | Sodium-independent transporter of chloride and iodide. {ECO:0000269|PubMed:10192399}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. {ECO:0000250}. |
Tissue Specificity | High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues. |
Top Pathways | Thyroid hormone synthesis |
Pendrin CRISPR/Cas9 KO Plasmid (h) - sc-401272 from Santa Cruz Biotechnology
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Pendrin HDR Plasmid (h) - sc-401272-HDR from Santa Cruz Biotechnology
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Pendrin Double Nickase Plasmid (h) - sc-401272-NIC from Santa Cruz Biotechnology
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Pendrin Double Nickase Plasmid (h2) - sc-401272-NIC-2 from Santa Cruz Biotechnology
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Pendrin CRISPR Activation Plasmid (h) - sc-401272-ACT from Santa Cruz Biotechnology
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Pendrin CRISPR Activation Plasmid (h2) - sc-401272-ACT-2 from Santa Cruz Biotechnology
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Pendrin Lentiviral Activation Particles (h) - sc-401272-LAC from Santa Cruz Biotechnology
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Pendrin Lentiviral Activation Particles (h2) - sc-401272-LAC-2 from Santa Cruz Biotechnology
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Pendrin siRNA (h) - sc-44009 from Santa Cruz Biotechnology
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Pendrin shRNA Plasmid (h) - sc-44009-SH from Santa Cruz Biotechnology
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Pendrin shRNA (h) Lentiviral Particles - sc-44009-V from Santa Cruz Biotechnology
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SLC26A4 RNAi - H00005172-R01 from Novus Biologicals
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MISSION® esiRNA - EHU034051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19525 from Sigma-Aldrich
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SLC26A4 siRNA (Human) - CRH3451 from Cohesion Biosciences
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SLC26A4 - MBS8235993 from MyBioSource
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shRNA set against Human SLC26A4 (NM_000441.1) - SHH409968 from Creative biogene
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shRNA set against Human SLC26A4(NM_000441.1) - SHL004284 from Creative biogene
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SLC26A4 shRNA Plasmid (Human) - CHH3451 from Cohesion Biosciences
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SLC26A4 miRNA 3'UTR clone - MiUTR1H-09496 from Creative biogene
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