FPGS

Gene Symbol FPGS
Entrez Gene 2356
Alt Symbol -
Species Human
Gene Type protein-coding
Description folylpolyglutamate synthase
Other Description folylpoly-gamma-glutamate synthetase|folylpolyglutamate synthase, mitochondrial|tetrahydrofolate synthase|tetrahydrofolylpolyglutamate synthase
Swissprots Q6P2P6 Q5JU19 B7Z2Z3 F5H0K6 B3KPW4 Q05932 Q5JU22
Accessions AAA85815 AAL08404 AAL08405 CCQ43291 EAW87698 EAW87699 EAW87700 EAW87701 Q05932 AK056920 BAG51826 AK295309 BAH12029 AK315523 BAG37904 AY007210 AY007211 AAL08406 AY007212 BC007121 BC009901 BC064393 AAH64393 BE302497 BF345926 BG328181 BT006639 AAP35285 CB854085 DA987755 DC365273 M98045 AAA35852 XM_005251864 XP_005251921 XM_011518437 XP_011516739 XM_011518438 XP_011516740 XM_011518439 XP_011516741 XR_242581 XR_242582 NM_001018078 NP_001018088 NM_001288803 NP_001275732 NM_004957 NP_004948 NR_110170
Function Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
Subcellular Location Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Top Pathways Folate biosynthesis

FPGS CRISPR/Cas9 KO Plasmid (h) - sc-407629 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS HDR Plasmid (h) - sc-407629-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS Double Nickase Plasmid (h) - sc-407629-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS Double Nickase Plasmid (h2) - sc-407629-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS CRISPR Activation Plasmid (h) - sc-407629-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS CRISPR Activation Plasmid (h2) - sc-407629-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS Lentiviral Activation Particles (h) - sc-407629-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS Lentiviral Activation Particles (h2) - sc-407629-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FPGS siRNA (h) - sc-92545 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FPGS shRNA Plasmid (h) - sc-92545-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FPGS shRNA (h) Lentiviral Particles - sc-92545-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FPGS RNAi - H00002356-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FPGS RNAi - H00002356-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU136591 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8923 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8923 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06029 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06029

FPGS siRNA (Human) - CRH1647 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FPGS - MBS8213070 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FPGS (NM_004957.4) - SHH296917 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FPGS(NM_004957.4) - SHH067493 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FPGS(NM_001018078.1) - SHH067511 from Creative biogene

Category siRNA
Species Reactivities Human

Human FPGS siRNA - orb262149 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FPGS shRNA Plasmid (Human) - CHH1647 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FPGS miRNA 3'UTR clone - MiUTR1H-03841 from Creative biogene

Species Reactivities Human
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