FPGS

Gene Symbol FPGS
Entrez Gene 2356
Alt Symbol -
Species Human
Gene Type protein-coding
Description folylpolyglutamate synthase
Other Description folylpoly-gamma-glutamate synthetase|folylpolyglutamate synthase, mitochondrial|tetrahydrofolate synthase|tetrahydrofolylpolyglutamate synthase
Swissprots Q6P2P6 Q5JU19 B7Z2Z3 F5H0K6 B3KPW4 Q05932 Q5JU22
Accessions AAA85815 AAL08404 AAL08405 CCQ43291 EAW87698 EAW87699 EAW87700 EAW87701 Q05932 AK056920 BAG51826 AK295309 BAH12029 AK315523 BAG37904 AY007210 AY007211 AAL08406 AY007212 BC007121 BC009901 BC064393 AAH64393 BE302497 BF345926 BG328181 BT006639 AAP35285 CB854085 DA987755 DC365273 M98045 AAA35852 XM_005251864 XP_005251921 XM_011518437 XP_011516739 XM_011518438 XP_011516740 XM_011518439 XP_011516741 XR_242581 XR_242582 NM_001018078 NP_001018088 NM_001288803 NP_001275732 NM_004957 NP_004948 NR_110170
Function Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
Subcellular Location Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Top Pathways Folate biosynthesis

FPGS (H-105) - sc-98479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FPGS (H-105): sc-98479. Western blot analysis of FPGS expression in U-698-M whole cell lysate.

Anti-Folylpolyglutamate synthase antibody - ab175849 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Folylpolyglutamate synthase antibody (ab175849) at 1/1000 dilutionLane 1 : K562 cell line lysateLane 2 : A2058 cell line lysateLysates/proteins at 35 µg per lane.

Anti-Folylpolyglutamate synthase antibody - ab82055 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab82055, at 1/100 diultion, staining of Formalin-fixed, paraffin-embedded, human liver carcinoma using Immunohistochemistry

Anti-Folylpolyglutamate synthase antibody - ab123120 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Folylpolyglutamate synthase antibody (ab123120) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-Folylpolyglutamate synthase antibody [EPR11064] - ab184564 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11064
Anti-Folylpolyglutamate synthase antibody [EPR11064] (ab184564) at 1/50000 dilution + K562 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Folylpolyglutamate synthase antibody, prediluted - ab82054 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab82054 (ready to use) staining of Formalin-fixed, paraffin-embedded Human liver carcinoma using Immunohistochemistry

Anti-FPGS Antibody (Internal, AP) - LS-C219358 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal, APC) - LS-C219360 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal, FITC) - LS-C219363 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal, Biotin) - LS-C219361 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal, Azide-free, HRP) - LS-C219362 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal, PE) - LS-C219364 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (Internal) - LS-C327394 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FPGS Antibody (aa265-314) - LS-C146171 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FPGS antibody LS-C146171 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-FPGS Antibody (Internal) - LS-C210526 from LifeSpan Bioscience

Prices $360.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Breast Carcinoma stained with anti-FPGS antibody

Anti-FPGS Antibody (aa304-330) - LS-C166246 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma with FPGS Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

FPGS Antibody - H00002356-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: FPGS Antibody [H00002356-A01] - FPGS polyclonal antibody (A01), Lot # 060626JCS1. Western Blot analysis of FPGS expression in Jurkat.

FPGS Antibody - NBP2-16526 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FPGS Antibody [NBP2-16526] - Analysis of FPGS expression in transfected 293T cell line by FPGS polyclonal antibody. A: Non-transfected lysate. B: FPGS transfected lysate. 7. 5% SDS PAGE gel, diluted at 1:1000.

FPGS Antibody - NBP1-35878 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Folylpolyglutamate synthase Antibody - bs-13196R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit

Folylpolyglutamate synthase Antibody, Cy3 Conjugated - bs-13196R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
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