Gene Symbol | BRAT1 |
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Entrez Gene | 221927 |
Alt Symbol | BAAT1, C7orf27, RMFSL |
Species | Human |
Gene Type | protein-coding |
Description | BRCA1-associated ATM activator 1 |
Other Description | BRCA1-associated protein required for ATM activation protein 1|HEAT repeat-containing protein C7orf27 |
Swissprots | Q6PJG6 Q9UFA3 Q8WVR8 A4D200 Q8IZ43 C9JY24 Q8IW85 Q96IV9 Q9H7J8 |
Accessions | EAL23957 EAW87255 EAW87256 EAW87257 EAW87258 EAW87259 EAW87260 Q6PJG6 AI963076 AK024482 BAB15772 AK131083 BAC85133 AK131097 BAC85147 AK311144 AL133088 CAB61405 BC007209 AAH07209 BC015632 AAH15632 BC023561 AAH23561 BC040704 AAH40704 BP363179 XM_005249643 XP_005249700 XM_011515177 XP_011513479 XM_011515178 XP_011513480 XM_011515179 XP_011513481 XM_011515180 XP_011513482 XM_011515181 XP_011513483 XM_011515182 XP_011513484 XM_011515183 XP_011513485 XM_011515184 XP_011513486 XM_011515185 XP_011513487 XM_011515186 XP_011513488 XM_011515187 XP_011513489 NM_152743 NP_689956 |
Function | Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM. {ECO:0000269|PubMed:16452482}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16452482}. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:16452482}. |
BRAT1 CRISPR/Cas9 KO Plasmid (h) - sc-415146 from Santa Cruz Biotechnology
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BRAT1 HDR Plasmid (h) - sc-415146-HDR from Santa Cruz Biotechnology
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BRAT1 Double Nickase Plasmid (h) - sc-415146-NIC from Santa Cruz Biotechnology
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BRAT1 Double Nickase Plasmid (h2) - sc-415146-NIC-2 from Santa Cruz Biotechnology
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BRAT1 CRISPR Activation Plasmid (h) - sc-415146-ACT from Santa Cruz Biotechnology
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BRAT1 CRISPR Activation Plasmid (h2) - sc-415146-ACT-2 from Santa Cruz Biotechnology
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BRAT1 Lentiviral Activation Particles (h) - sc-415146-LAC from Santa Cruz Biotechnology
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BRAT1 Lentiviral Activation Particles (h2) - sc-415146-LAC-2 from Santa Cruz Biotechnology
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BRAT1 siRNA (h) - sc-89333 from Santa Cruz Biotechnology
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BRAT1 shRNA Plasmid (h) - sc-89333-SH from Santa Cruz Biotechnology
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BRAT1 shRNA (h) Lentiviral Particles - sc-89333-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5085 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5085 from Sigma-Aldrich
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BRAT1 siRNA (Human) - CRJ6545 from Cohesion Biosciences
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BRAT1 - MBS8226540 from MyBioSource
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shRNA set against Human BRAT1 (NM_152743.3) - SHH247542 from Creative biogene
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Human BRAT1 siRNA - orb277046 from Biorbyt
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BRAT1 shRNA Plasmid (Human) - CHJ6545 from Cohesion Biosciences
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BRAT1 miRNA 3'UTR clone - MiUTR3H-13275 from Creative biogene
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