MID1

Gene Symbol	MID1
Entrez Gene	4281
Alt Symbol	BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY
Species	Human
Gene Type	protein-coding
Description	midline 1
Other Description	E3 ubiquitin-protein ligase Midline-1|Opitz/BBB syndrome|RING finger protein 59|RING finger protein Midline-1|midline 1 RING finger protein|putative transcription factor XPRF|tripartite motif protein TRIM18|tripartite motif-containing protein 18|zinc finger on X and Y, mouse, homolog of
Swissprots	O15344 O75361 B2RCG2 Q9BZX5
Accessions	EAW98779 EAW98780 EAW98781 O15344 AF035360 AAB99951 AF041206 AAC32998 AF041208 AAC33000 AF041210 AAC33002 AF230976 AAG50191 AF230977 AAG50192 AF269101 AAG33130 AI371111 AK025187 AK226104 AK291215 BAF83904 AK297205 BAG59690 AK299061 BAH12942 AK315095 BAG37559 AY112900 AY112901 AY112903 AY539962 AY539963 AY539964 AY539965 AY539966 AY539967 AY539969 AY539970 AY539971 AY539972 AY539973 AY539974 AY539975 AY539976 AY539977 AY539978 AY539979 AY539980 AY539981 AY539982 AY539983 AY539984 AY539985 AY539986 AY539987 AY539988 AY539989 AY539990 AY539991 AY539992 AY539993 AY539994 AY539995 AY539996 AY539997 AY539998 AY539999 AY540000 AY540001 AY540002 AY540003 AY540004 AY540005 AY540006 AY540007 AY540008 AY540009 AY540010 AY540011 AY540012 AY540013 AY540014 AY540015 AY540016 AY540017 AY540018 AY540020 AY540021 AY540022 AY540023 AY540024 AY660577 AY660578 AY660579 BC053626 AAH53626 DA435613 DA856308 DC309977 DC369426 EF217423 EF217424 EF217425 EF217426 EF532594 EF532595 EF532596 EU446510 ABZ92039 HG512432 HG512433 HG512434 HG512435 Y13667 CAA74018 XM_005274536 XP_005274593 XM_005274537 XP_005274594 XM_005274538 XP_005274595 XM_006724492 XP_006724555 XM_006724493 XP_006724556 XM_011545525 XP_011543827 XM_011545526 XP_011543828 XM_011545527 XP_011543829 NM_000381 NP_000372 NM_001098624 NP_001092094 NM_001193277 NP_001180206 NM_001193278 NP_001180207 NM_001193279 NP_001180208 NM_001193280 NP_001180209 NM_001193281 NP_001180210 NM_033289 NP_150631 NM_033290 NP_150632 NM_033291
Function	Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.
Tissue Specificity	In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat MID1 ELISA Kit (Cell-Based ELISA) - LS-F3006 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse MID1 ELISA Kit (Sandwich ELISA) - LS-F9311 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.052 ng/ml Range 0.156-10 ng/ml

Midline-1 (MID1), Human, ELISA Kit - CSB-EL013819HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Midline 1, ELISA Kit - MBS052547 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS086140 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS098968 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS066204 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS077246 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS098767 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1, ELISA Kit - MBS064750 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Midline 1 (MID1), ELISA Kit - MBS2021675 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.052ng/mL. Range 0.156-10ng/mL

midline 1 (Opitz/BBB syndrome) , ELISA Kit - MBS941500 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human MID1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.44 pg/ml -1500 pg/ml.

TRI18 Colorimetric Cell-Based ELISA - CB5777 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ELISA Kit for Midline 1 (MID1) - SEC620Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.052ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Midline-1(MID1) ELISA kit - CSB-EL013819HU from Cusabio Category ELISA Kit Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Rabbit Osterix ELISA - E04O0004 from BlueGene Biotech Category ELISA Kit

Human OSX ELISA Kit - abx573162 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human MID1 ELISA Kit - E024538 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human MID1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human OSX ELISA Kit - E027880 from Biobool Category ELISA Kit Sensitivity Typically less than 0.057ng/mL.

MID1 ELISA Kit (Human) (OKCA00727) - OKCA00727 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 5.86 pg/mL Range 23.44 pg/mL-1,500 pg/mL

Human Midline-1 (MID1) ELISA Kit - AE33520HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Midline 1 (MID1), ELISA Kit - MBS9376441 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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