MID1

Gene Symbol	MID1
Entrez Gene	4281
Alt Symbol	BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY
Species	Human
Gene Type	protein-coding
Description	midline 1
Other Description	E3 ubiquitin-protein ligase Midline-1|Opitz/BBB syndrome|RING finger protein 59|RING finger protein Midline-1|midline 1 RING finger protein|putative transcription factor XPRF|tripartite motif protein TRIM18|tripartite motif-containing protein 18|zinc finger on X and Y, mouse, homolog of
Swissprots	O15344 O75361 B2RCG2 Q9BZX5
Accessions	EAW98779 EAW98780 EAW98781 O15344 AF035360 AAB99951 AF041206 AAC32998 AF041208 AAC33000 AF041210 AAC33002 AF230976 AAG50191 AF230977 AAG50192 AF269101 AAG33130 AI371111 AK025187 AK226104 AK291215 BAF83904 AK297205 BAG59690 AK299061 BAH12942 AK315095 BAG37559 AY112900 AY112901 AY112903 AY539962 AY539963 AY539964 AY539965 AY539966 AY539967 AY539969 AY539970 AY539971 AY539972 AY539973 AY539974 AY539975 AY539976 AY539977 AY539978 AY539979 AY539980 AY539981 AY539982 AY539983 AY539984 AY539985 AY539986 AY539987 AY539988 AY539989 AY539990 AY539991 AY539992 AY539993 AY539994 AY539995 AY539996 AY539997 AY539998 AY539999 AY540000 AY540001 AY540002 AY540003 AY540004 AY540005 AY540006 AY540007 AY540008 AY540009 AY540010 AY540011 AY540012 AY540013 AY540014 AY540015 AY540016 AY540017 AY540018 AY540020 AY540021 AY540022 AY540023 AY540024 AY660577 AY660578 AY660579 BC053626 AAH53626 DA435613 DA856308 DC309977 DC369426 EF217423 EF217424 EF217425 EF217426 EF532594 EF532595 EF532596 EU446510 ABZ92039 HG512432 HG512433 HG512434 HG512435 Y13667 CAA74018 XM_005274536 XP_005274593 XM_005274537 XP_005274594 XM_005274538 XP_005274595 XM_006724492 XP_006724555 XM_006724493 XP_006724556 XM_011545525 XP_011543827 XM_011545526 XP_011543828 XM_011545527 XP_011543829 NM_000381 NP_000372 NM_001098624 NP_001092094 NM_001193277 NP_001180206 NM_001193278 NP_001180207 NM_001193279 NP_001180208 NM_001193280 NP_001180209 NM_001193281 NP_001180210 NM_033289 NP_150631 NM_033290 NP_150632 NM_033291
Function	Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.
Tissue Specificity	In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MID1 protein fragment - ab114762 from Abcam Category Protein Source Wheat germ Species Human

MID1 Antibody Blocking Peptide - LS-E2444 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MID1 Antibody Blocking Peptide - LS-E21234 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MID1 Protein - H00004281-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MID1-Antibody-C-term-Blocking-peptide - BP13465b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Midline-1 - H00004281-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Midline-1 - H00004281-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human MID1 - MID1-30200TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Midline 1 (MID1) - RPC620Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Midline 1 (MID1) - RPC620Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Midline-1 (E103) Peptide - BS2451P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Midline-1(MID1) - CSB-YP013819HU CSB-EP013819HU CSB-BP013819HU CSB-MP013819HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Midline-1 (transcript variant 1) - TP308776 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Midline-1 (transcript variant 3) - TP311781 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Midline-1 (transcript variant 4) - TP313454 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MID1 Blocking Peptide - abx061628 from Abbexa Category Peptide

MID1 Peptide, Human - M34GP09512H from Creative Peptides Category Peptide Source Synthetic. Species Human

MID1 Blocking Peptide - CBP7018 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Monkey

MID1 peptide - orb339235 from Biorbyt Category Peptide Prices $213.00, $417.00 Sizes 1 mg, 5 mg

Midline 1, Recombinant Protein - MBS2030329 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Midline-1 (MID1), Recombinant Protein - MBS1203398 from MyBioSource Category Protein Prices $1,470.00, $1,470.00, $1,695.00, $1,695.00, $2,500.00, $2,500.00, $2,940.00, $2,940.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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