FKRP

Gene Symbol	FKRP
Entrez Gene	79147
Alt Symbol	LGMD2I, MDC1C, MDDGA5, MDDGB5, MDDGC5
Species	Human
Gene Type	protein-coding
Description	fukutin related protein
Other Description	fukutin-related protein
Swissprots	A8K5G7 Q9H9S5
Accessions	CAE90537 EAW57444 EAW57445 Q9H9S5 AJ314847 CAC85633 AK022638 BAB14146 AK095497 BAG53071 AK291282 BAF83971 AW504292 BC002612 AAH02612 BM979509 CX866271 DA123579 DB090073 DN999716 DQ893605 ABM84531 DQ895127 ABM86053 XM_005259247 XP_005259304 XM_005259248 XP_005259305 XM_005259249 XP_005259306 XM_005259250 XP_005259307 XM_011527301 XP_011525603 XM_011527302 XP_011525604 XM_011527303 XP_011525605 XM_011527304 XP_011525606 XM_011527305 XP_011525607 XM_011527306 XP_011525608 XM_011527307 XP_011525609 NM_001039885 NP_001034974 NM_024301 NP_077277
Function	Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:25279699}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein. Secreted. Cell membrane, sarcolemma {ECO:0000250}. Rough endoplasmic reticulum. Note=According to some studies the N- terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted. Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to-trans-cisternae, as assessed by MG160 colocalization. Detected in rough endoplasmic reticulum in myocytes. In general, mutants associated with severe clinical phenotypes are retained within the endoplasmic reticulum.
Tissue Specificity	Expressed predominantly in skeletal muscle, placenta, and heart and relatively weakly in brain, lung, liver kidney and pancreas.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

FKRP 293 Cell Lysate - 405679 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

FKRP Overexpression Lysate (Native) - NBL1-10743 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FKRP Overexpression Lysate (Native) - NBP2-08534 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FKRP Overexpression Lysate (Native) - NBP2-09208 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FKRP (h): 293 Lysate - sc-159806 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

FKRP Over-expression Lysate Product - GWB-91D970 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

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