| Gene Symbol |
FNIP1
|
| Entrez Gene |
96459
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
folliculin interacting protein 1
|
| Other Description |
folliculin-interacting protein 1
|
| Swissprots |
Q9BUT0 Q86T47 D6RJH5 Q8TF40
|
| Accessions |
EAW62364 Q8TF40 AB075841 BAB85547 AK126675 BAG54356 AK292473 BAF85162 AL832008 CAD91145 AL834127 BC001956 AAH01956 BC156495 AAI56496 BC172496 AAI72496 CR749426 CAH18264 CR936723 DQ145719 AAZ65854 NM_001008738 NP_001008738 NM_133372 NP_588613
|
| Function |
May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18663353}. Note=Colocalizes with FLCN in the cytoplasm.
|
| Tissue Specificity |
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18403135}.
|