Gene Symbol | FNIP1 |
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Entrez Gene | 96459 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | folliculin interacting protein 1 |
Other Description | folliculin-interacting protein 1 |
Swissprots | Q9BUT0 Q86T47 D6RJH5 Q8TF40 |
Accessions | EAW62364 Q8TF40 AB075841 BAB85547 AK126675 BAG54356 AK292473 BAF85162 AL832008 CAD91145 AL834127 BC001956 AAH01956 BC156495 AAI56496 BC172496 AAI72496 CR749426 CAH18264 CR936723 DQ145719 AAZ65854 NM_001008738 NP_001008738 NM_133372 NP_588613 |
Function | May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18663353}. Note=Colocalizes with FLCN in the cytoplasm. |
Tissue Specificity | Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18403135}. |
FNIP1 CRISPR/Cas9 KO Plasmid (h) - sc-413998 from Santa Cruz Biotechnology
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FNIP1 HDR Plasmid (h) - sc-413998-HDR from Santa Cruz Biotechnology
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FNIP1 Double Nickase Plasmid (h) - sc-413998-NIC from Santa Cruz Biotechnology
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FNIP1 Double Nickase Plasmid (h2) - sc-413998-NIC-2 from Santa Cruz Biotechnology
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FNIP1 CRISPR Activation Plasmid (h) - sc-413998-ACT from Santa Cruz Biotechnology
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FNIP1 CRISPR Activation Plasmid (h2) - sc-413998-ACT-2 from Santa Cruz Biotechnology
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FNIP1 Lentiviral Activation Particles (h) - sc-413998-LAC from Santa Cruz Biotechnology
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FNIP1 Lentiviral Activation Particles (h2) - sc-413998-LAC-2 from Santa Cruz Biotechnology
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FNIP1 siRNA (h) - sc-91673 from Santa Cruz Biotechnology
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FNIP1 shRNA Plasmid (h) - sc-91673-SH from Santa Cruz Biotechnology
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FNIP1 shRNA (h) Lentiviral Particles - sc-91673-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN8861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8861 from Sigma-Aldrich
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FNIP1 siRNA (Human) - CRJ4267 from Cohesion Biosciences
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FNIP1 - MBS8223304 from MyBioSource
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shRNA set against Human FNIP1 (NM_001008738.2) - SHH296205 from Creative biogene
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shRNA set against Human FNIP1(NM_133372.2) - SHH065099 from Creative biogene
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FNIP1 shRNA Plasmid (Human) - CHJ4267 from Cohesion Biosciences
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FNIP1 miRNA 3'UTR clone - MiUTR1H-03797 from Creative biogene
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FNIP1 miRNA 3'UTR clone - MiUTR1H-03798 from Creative biogene
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