| Gene Symbol |
SUN2
|
| Entrez Gene |
25777
|
| Alt Symbol |
UNC84B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Sad1 and UNC84 domain containing 2
|
| Other Description |
SUN domain-containing protein 2|Sad1 unc-84 domain protein 2|nuclear envelope protein|protein unc-84 homolog B|rab5-interacting protein|rab5IP|sad1/unc-84 protein-like 2|unc-84 homolog B
|
| Swissprots |
Q504T5 O75156 Q6B4H1 Q2NKN8 Q9UH99 B0QY62 Q7Z3E3 Q2T9F7
|
| Accessions |
EAW60265 EAW60266 EAW60267 EAW60268 EAW60269 EAW60270 EAW60271 Q9UH99 AB014568 BAA31643 AF038178 AF202723 AAF15887 AK295787 BAG58608 AK304188 BAG65068 AM392760 CAL37638 AY682988 AAT90500 BC030684 AAH30684 BC069253 AAH69253 BC094797 AAH94797 BC111549 AAI11550 BC111717 AAI11718 BE675617 BI908715 BX537962 CAD97926 CB988569 CD365855 CN299688 CR456474 CAG30360 CU013024 CAK54455 CU013312 CAK54754 DC400744 XM_011530104 XP_011528406 XM_011530105 XP_011528407 NM_001199579 NP_001186508 NM_001199580 NP_001186509 NM_015374 NP_056189
|
| Function |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000269|Pu
|
| Subcellular Location |
Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:12393179}.
|
![Western Blot: UNC84B Overexpression Lysate (Adult Normal) [NBP2-07182] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UNC84B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4974_UNC84B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07182-img0001.jpg)