SUN2

Gene Symbol SUN2
Entrez Gene 25777
Alt Symbol UNC84B
Species Human
Gene Type protein-coding
Description Sad1 and UNC84 domain containing 2
Other Description SUN domain-containing protein 2|Sad1 unc-84 domain protein 2|nuclear envelope protein|protein unc-84 homolog B|rab5-interacting protein|rab5IP|sad1/unc-84 protein-like 2|unc-84 homolog B
Swissprots Q504T5 O75156 Q6B4H1 Q2NKN8 Q9UH99 B0QY62 Q7Z3E3 Q2T9F7
Accessions EAW60265 EAW60266 EAW60267 EAW60268 EAW60269 EAW60270 EAW60271 Q9UH99 AB014568 BAA31643 AF038178 AF202723 AAF15887 AK295787 BAG58608 AK304188 BAG65068 AM392760 CAL37638 AY682988 AAT90500 BC030684 AAH30684 BC069253 AAH69253 BC094797 AAH94797 BC111549 AAI11550 BC111717 AAI11718 BE675617 BI908715 BX537962 CAD97926 CB988569 CD365855 CN299688 CR456474 CAG30360 CU013024 CAK54455 CU013312 CAK54754 DC400744 XM_011530104 XP_011528406 XM_011530105 XP_011528407 NM_001199579 NP_001186508 NM_001199580 NP_001186509 NM_015374 NP_056189
Function Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000269|Pu
Subcellular Location Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:12393179}.

SUN2 (H-4) - sc-376881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SUN2 (H-4): sc-376881. Western blot analysis of SUN2 expression in Jurkat whole cell lysate.

SUN2 (G-12) - sc-86892 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SUN2 (G-12): sc-86892. Western blot analysis of SUN2 expression in Jurkat whole cell lysate.

SUN2 (H-145) - sc-366763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SUN2 (H-145): sc-366763. Western blot analysis of SUN2 expression in MDA-MB-435S whole cell lysate.

SUN2 (G-5) - sc-377459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SUN2 (G-5): sc-377459. Western blot analysis of SUN2 expression in Jurkat whole cell lysate.

SUN2 (15A) - sc-136427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SUN2 (15A): sc-136427. Western blot analysis of SUN2 expression in HeLa whole cell lysate.

SUN2 (S-16) - sc-86894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SUN2 fragment (Q-21) - sc-134046 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
SUN2 fragment (Q-21): sc-134046. Western blot analysis of SUN2 fragment expression in Hep G2 whole cell lysate.

Anti-SUN2 antibody - ab65447 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SUN2 antibody (ab65447) at 1 µg/ml + Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SUN2 antibody - ab170658 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SUN2 antibody (ab170658) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-SUN2 antibody [EPR6556] - ab133591 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6556
All lanes : Anti-SUN2 antibody [EPR6556] (ab133591) at 1/1000 dilutionLane 1 : Human fetal muscle tissue lysateLane 2 : Saos 2 cell lysateLane 3 : HeLa cell lysate Lane 4 : HepG cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-SUN2 antibody [EPR6557] - ab124916 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6557
ab124916 staining SUN2 in mouse testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed and paraffin-embedded, antigen retrieval was by heat mediation in Tris/EDTA buffer pH9. Samples were incubated with primary antibody (1/500). An HRP-conjugated goat anti-rabbit IgG, ab97051 (1/500) was used as the secondary antibody. Tissue counterstained with Hematoxylin. PBS was used in the negative control rather than the Primary antibody.

Anti-SUN2 antibody [EPR6557] (Alexa Fluor® 488) - ab198981 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6557
Overlay histogram showing HeLa cells stained with ab198981 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab198981, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-SUN2 antibody [EPR6557] (Alexa Fluor® 647) - ab198985 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6557
Overlay histogram showing HeLa cells stained with ab198985 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab198985, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 647 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a solid-state 25mW red diode laser (635 nm) and 675/30 bandpass filter.

Anti-UNC84B / SUN2 Antibody (aa237-265, AP) - LS-C242446 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa237-265, Biotin) - LS-C242447 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa237-265, FITC) - LS-C242448 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa237-265, APC) - LS-C242449 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa237-265, PE) - LS-C242452 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa237-265, Azide-free, HRP) - LS-C247195 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa236-265) - LS-C326200 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (Biotin) - LS-C347845 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody - LS-C348224 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-UNC84B / SUN2 Antibody (aa75-124) - LS-C81485 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-UNC84B / SUN2 Antibody (Internal, clone EPR6556) - LS-C138975 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6556
Western blot analysis on (A) fetal muscle, (B) Saos-2, (C) HeLa, and (D) HepG2 cell lysates using anti-SUN2 antibody.

Anti-UNC84B / SUN2 Antibody (aa326-375) - LS-C82502 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.
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