| Gene Symbol |
JAM2
|
| Entrez Gene |
58494
|
| Alt Symbol |
C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
junctional adhesion molecule 2
|
| Other Description |
JAM-2|JAM-IT/VE-JAM|junctional adhesion molecule B|vascular endothelial junction-associated molecule
|
| Swissprots |
Q6UXG6 Q6YNC1 B4DGT9 B2R6T9 P57087
|
| Accessions |
EAX09976 EAX09977 EAX09978 P57087 AF255910 AAF81223 AI742752 AK056079 AK294769 BAG57900 AK312708 BAG35586 AM392801 CAL37679 AM392870 CAL37748 AM393811 CAL38686 AX772824 CAE06261 AY016009 AAG49022 AY077698 AAL82538 AY358361 AAQ88727 BC017779 AAH17779 BG540412 BM804795 BM921497 CX870550 XR_937537 NM_001270408 NP_001257337 NM_021219 NP_067042 NR_072999 NM_001270407 NP_001257336
|
| Function |
May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
|
| Subcellular Location |
Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.
|
| Tissue Specificity |
Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells. {ECO:0000269|PubMed:10779521}.
|
| Top Pathways |
Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection
|
![Western Blot: Junctional Adhesion Molecule 2 Overexpression Lysate (Adult Normal) [NBP2-04384] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Junctional Adhesion Molecule 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/23025_Junctional%2520Adhesion%2520Molecule%25202%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04384-img0001.jpg)