| Gene Symbol |
GPR55
|
| Entrez Gene |
9290
|
| Alt Symbol |
LPIR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 55
|
| Other Description |
G-protein coupled receptor 55
|
| Swissprots |
Q8N580 Q9Y2T6
|
| Accessions |
AAD22410 EAW70939 EAW70940 Q9Y2T6 AK292223 BAF84912 BC032694 AAH32694 CR541776 CAG46575 DQ890881 ABM81807 DQ894035 ABM84961 FJ348259 ACI96303 XM_005246952 XP_005247009 XM_011512175 XP_011510477 XM_011512176 XP_011510478 XM_011512177 XP_011510479 NM_005683 NP_005674
|
| Function |
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. {ECO:0000250, ECO:0000269|PubMed:19805329}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18757503}; Multi-pass membrane protein {ECO:0000269|PubMed:18757503}.
|
| Tissue Specificity |
Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. {ECO:0000269|PubMed:19805329, ECO:0000269|PubMed:9931487}.
|
![Western Blot: GPR55 Overexpression Lysate (Adult Normal) [NBL1-11284] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GPR55.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8065_GPR55%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11284-img0002.jpg)