Gene Symbol | PHOSPHO1 |
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Entrez Gene | 162466 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | phosphatase, orphan 1 |
Other Description | phosphoethanolamine/phosphocholine phosphatase |
Swissprots | Q8TCT1 E9PAM0 Q17RU6 |
Accessions | CAD33279 CAE84349 CAE84350 EAW94686 Q8TCT1 AJ457189 CAD29803 BC029931 BC117187 AAI17188 BC143884 XM_005257109 XP_005257166 XM_006721731 XP_006721794 XM_006721732 XP_006721795 NM_001143804 NP_001137276 NM_178500 NP_848595 |
Function | Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. |
Tissue Specificity | Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269|PubMed:15050893}. |
Top Pathways | Glycerophospholipid metabolism |
PHOSPHO1 CRISPR/Cas9 KO Plasmid (h) - sc-414841 from Santa Cruz Biotechnology
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PHOSPHO1 HDR Plasmid (h) - sc-414841-HDR from Santa Cruz Biotechnology
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PHOSPHO1 Double Nickase Plasmid (h) - sc-414841-NIC from Santa Cruz Biotechnology
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PHOSPHO1 Double Nickase Plasmid (h2) - sc-414841-NIC-2 from Santa Cruz Biotechnology
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PHOSPHO1 CRISPR Activation Plasmid (h) - sc-414841-ACT from Santa Cruz Biotechnology
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PHOSPHO1 CRISPR Activation Plasmid (h2) - sc-414841-ACT-2 from Santa Cruz Biotechnology
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PHOSPHO1 Lentiviral Activation Particles (h) - sc-414841-LAC from Santa Cruz Biotechnology
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PHOSPHO1 Lentiviral Activation Particles (h2) - sc-414841-LAC-2 from Santa Cruz Biotechnology
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PHOSPHO1 siRNA (h) - sc-93674 from Santa Cruz Biotechnology
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PHOSPHO1 shRNA Plasmid (h) - sc-93674-SH from Santa Cruz Biotechnology
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PHOSPHO1 shRNA (h) Lentiviral Particles - sc-93674-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110581 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0415 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0417 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0416 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16751 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06415 from Sigma-Aldrich
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PHOSPHO1 siRNA (Human) - CRJ5950 from Cohesion Biosciences
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PHOSPHO1 RNAi - H00162466-R01 from Novus Biologicals
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shRNA set against Human PHOSPHO1 (NM_178500.3) - SHH375020 from Creative biogene
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PHOSPHO1 shRNA Plasmid (Human) - CHJ5950 from Cohesion Biosciences
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PHOSPHO1 miRNA 3'UTR clone - MiUTR3H-15705 from Creative biogene
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PHOSPHO1 miRNA 3'UTR clone - MiUTR3H-15706 from Creative biogene
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