NFATC1

Gene Symbol	NFATC1
Entrez Gene	4772
Alt Symbol	NF-ATC, NFAT2, NFATc
Species	Human
Gene Type	protein-coding
Description	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Other Description	NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytoplasmic 1
Swissprots	Q12865 B5B2M7 B5B2M4 Q2M1S3 B5B2M9 B5B2M6 B5B2M5 O95644 Q15793 B5B2M8 B5B2N1
Accessions	CBX47640 CBX47641 CBX47642 CBX47643 CBX47644 EAW66617 EAW66618 EAW66619 EAW66620 EAW66621 EAW66622 O95644 AA621079 AA679278 AK292641 BAF85330 AK293760 BAG57179 AK309546 AW014910 BC033848 BC045628 BC104753 AAI04754 BC112243 AAI12244 BC143457 BF515172 EU887559 ACG55579 EU887560 ACG55580 EU887561 ACG55581 EU887562 ACG55582 EU887563 ACG55583 EU887564 ACG55584 EU887565 ACG55585 EU887566 ACG55586 HY039825 U08015 AAA19601 U59736 AAC50869 U80917 AAD00450 U80918 AAD00451 U80919 AAD00452 X99829 CAA68146 NM_001278669 NP_001265598 NM_001278670 NP_001265599 NM_001278672 NP_001265601 NM_001278673 NP_001265602 NM_001278675 NP_001265604 NM_006162 NP_006153 NM_172387 NP_765975 NM_172388 NP_765976 NM_172389 NP_765977 NM_172390 NP_765978
Function	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity	Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269|PubMed:18675896}.
Top Pathways	cAMP signaling pathway, Wnt signaling pathway, Inflammatory bowel disease (IBD), cGMP-PKG signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse NFATC1 / NFAT2 ELISA Kit (Sandwich ELISA) - LS-F7657 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), Human, ELISA Kit - CSB-EL015745HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), Human, ELISA Kit - E01N0544 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Nuclear factor of activated T-cells, cytoplasmic 1, NFATC1, Human, ELISA Kit - E1519h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Nuclear factor of activated T cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7201032 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS053658 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS092323 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS101817 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS106462 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS100583 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS049138 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear Factor of Activated T-Cells, Cytoplasmic 1, ELISA Kit - MBS094708 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7203072 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7231312 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7236705 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7218537 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7234162 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7220667 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7243208 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), ELISA Kit - MBS7246332 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, ELISA Kit - MBS920738 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 6.25 pg/ml. Range 25 pg/ml -1600 pg/ml.

ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) - SEL941Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

NF-Atc Factor, human - DP-10141-X from Nordic BioSite

Human Nuclear factor of activated T-cells, cytoplasmic 1(NFATC1) ELISA kit - CSB-EL015745HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Bovine NFATC1 / NFAT2 ELISA Kit (Custom ELISA) - LS-F17887 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

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