| Gene Symbol | NFATC1 |
|---|---|
| Entrez Gene | 4772 |
| Alt Symbol | NF-ATC, NFAT2, NFATc |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
| Other Description | NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytoplasmic 1 |
| Swissprots | Q12865 B5B2M7 B5B2M4 Q2M1S3 B5B2M9 B5B2M6 B5B2M5 O95644 Q15793 B5B2M8 B5B2N1 |
| Accessions | CBX47640 CBX47641 CBX47642 CBX47643 CBX47644 EAW66617 EAW66618 EAW66619 EAW66620 EAW66621 EAW66622 O95644 AA621079 AA679278 AK292641 BAF85330 AK293760 BAG57179 AK309546 AW014910 BC033848 BC045628 BC104753 AAI04754 BC112243 AAI12244 BC143457 BF515172 EU887559 ACG55579 EU887560 ACG55580 EU887561 ACG55581 EU887562 ACG55582 EU887563 ACG55583 EU887564 ACG55584 EU887565 ACG55585 EU887566 ACG55586 HY039825 U08015 AAA19601 U59736 AAC50869 U80917 AAD00450 U80918 AAD00451 U80919 AAD00452 X99829 CAA68146 NM_001278669 NP_001265598 NM_001278670 NP_001265599 NM_001278672 NP_001265601 NM_001278673 NP_001265602 NM_001278675 NP_001265604 NM_006162 NP_006153 NM_172387 NP_765975 NM_172388 NP_765976 NM_172389 NP_765977 NM_172390 NP_765978 |
| Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Tissue Specificity | Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269|PubMed:18675896}. |
| Top Pathways | cAMP signaling pathway, Wnt signaling pathway, Inflammatory bowel disease (IBD), cGMP-PKG signaling pathway, Oxytocin signaling pathway |