| Gene Symbol | CANX |
|---|---|
| Entrez Gene | 821 |
| Alt Symbol | CNX, IP90, P90 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calnexin |
| Other Description | major histocompatibility complex class I antigen-binding protein p88 |
| Swissprots | D6R9K3 B4DGP8 B4E2T8 P27824 D3DWQ3 B2R5V8 |
| Accessions | CCD35249 EAW53802 EAW53803 EAW53804 EAW53805 P27824 AF070646 AJ271880 CAB72137 AK129990 BAC85269 AK130080 AK294702 BAG57859 AK304420 BAG65250 AK312334 BAG35255 BC003552 AAH03552 BC042843 AAH42843 BC050534 DQ890627 ABM92244 DQ893794 ABM84720 L10284 AAA36125 L18887 AAA21013 M94859 AAA21749 M98452 AAA35696 S67659 AAB29309 XM_011534664 XP_011532966 XM_011534665 XP_011532967 NM_001024649 NP_001019820 NM_001746 NP_001737 |
| Function | Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER. |
| Top Pathways | Phagosome, Protein processing in endoplasmic reticulum, HTLV-I infection, Thyroid hormone synthesis, Antigen processing and presentation |