| Gene Symbol | PIP4K2A |
|---|---|
| Entrez Gene | 5305 |
| Alt Symbol | PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha |
| Other Description | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha|1-phosphatidylinositol-4-phosphate kinase|1-phosphatidylinositol-4-phosphate-5-kinase|1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha|PI(5)P 4-kinase type II alpha|PIP4KII-alpha|PIP5KIII|PIP5KIIalpha|PtdIns(4)P-5-kinase B isoform|diphosphoinositide kinase 2-alpha|phosphatidylinositol 5-phosphate 4-kinase type II alpha|phosphatidylinositol 5-phosphate 4-kinase type-2 alpha|phosphatidylinositol-4-phosphate 5-kinase, type II, alpha|phosphatidylinositol-5-phosphate 4-kinase type-2 alpha|ptdIns(4)P-5-kinase C isoform|ptdIns(5)P-4-kinase isoform 2-alpha|type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform |
| Swissprots | P48426 B4DGX2 D3DRV1 P53807 Q5VUX3 B0YJ66 |
| Accessions | ACA06044 ACA06045 EAW86140 EAW86141 P48426 AK023329 AK294817 BAG57933 AK294867 BAG57970 BC018034 AAH18034 DB504104 S78798 AAB35041 U14957 AAA64835 XM_006717450 XP_006717513 XM_011519494 XP_011517796 XM_011519495 XP_011517797 XM_011519496 XP_011517798 XM_011519497 XP_011517799 NM_005028 NP_005019 |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269|PubMed:18364242}. |
| Subcellular Location | Cell membrane {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}. |
| Tissue Specificity | Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}. |
| Top Pathways | Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system |