PIP4K2A

Gene Symbol	PIP4K2A
Entrez Gene	5305
Alt Symbol	PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Other Description	1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha|1-phosphatidylinositol-4-phosphate kinase|1-phosphatidylinositol-4-phosphate-5-kinase|1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha|PI(5)P 4-kinase type II alpha|PIP4KII-alpha|PIP5KIII|PIP5KIIalpha|PtdIns(4)P-5-kinase B isoform|diphosphoinositide kinase 2-alpha|phosphatidylinositol 5-phosphate 4-kinase type II alpha|phosphatidylinositol 5-phosphate 4-kinase type-2 alpha|phosphatidylinositol-4-phosphate 5-kinase, type II, alpha|phosphatidylinositol-5-phosphate 4-kinase type-2 alpha|ptdIns(4)P-5-kinase C isoform|ptdIns(5)P-4-kinase isoform 2-alpha|type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
Swissprots	P48426 B4DGX2 D3DRV1 P53807 Q5VUX3 B0YJ66
Accessions	ACA06044 ACA06045 EAW86140 EAW86141 P48426 AK023329 AK294817 BAG57933 AK294867 BAG57970 BC018034 AAH18034 DB504104 S78798 AAB35041 U14957 AAA64835 XM_006717450 XP_006717513 XM_011519494 XP_011517796 XM_011519495 XP_011517797 XM_011519496 XP_011517798 XM_011519497 XP_011517799 NM_005028 NP_005019
Function	Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269|PubMed:18364242}.
Subcellular Location	Cell membrane {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.
Tissue Specificity	Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}.
Top Pathways	Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PIP4K2A (D83C1) Rabbit mAb - 5527 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D83C1

PIPK II (D-3) - sc-393246 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PIPK II (N-19) - sc-1330 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIPK II α (N-20) - sc-33886 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIPK II α (149.1) - sc-100406 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

PIPK II α/β (K-16) - sc-33887 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PIP5K2 alpha antibody - ab37799 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIP5K2 alpha antibody - ab5469 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIP5K2 alpha antibody - ab118267 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIP5K2 alpha antibody - ab55597 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PIP5K2 alpha antibody [3A3] - ab125107 from Abcam Prices $464.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3A3

Anti-PIP5K2 alpha antibody [3A9] - ab117967 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A9

Anti-PIP5K2 alpha antibody [EPR3760(2)] - ab109128 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3760(2)

Anti-PIP5K2 alpha antibody - N-terminal - ab154585 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (N-Terminus, AP) - LS-C280816 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (N-Terminus, APC) - LS-C280817 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (aa107-156) - LS-C107756 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (N-Terminus, Biotin) - LS-C280818 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (aa303-335) - LS-C101117 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (aa287-336) - LS-C107912 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (N-Terminus, Azide-free, HRP) - LS-C280819 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (N-Terminus, PE) - LS-C280820 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (C-Terminus, AP) - LS-C280821 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (C-Terminus, APC) - LS-C280822 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIP4K2A / PIPK Antibody (C-Terminus, Biotin) - LS-C280823 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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