PIP4K2A

Gene Symbol	PIP4K2A
Entrez Gene	5305
Alt Symbol	PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Other Description	1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha|1-phosphatidylinositol-4-phosphate kinase|1-phosphatidylinositol-4-phosphate-5-kinase|1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha|PI(5)P 4-kinase type II alpha|PIP4KII-alpha|PIP5KIII|PIP5KIIalpha|PtdIns(4)P-5-kinase B isoform|diphosphoinositide kinase 2-alpha|phosphatidylinositol 5-phosphate 4-kinase type II alpha|phosphatidylinositol 5-phosphate 4-kinase type-2 alpha|phosphatidylinositol-4-phosphate 5-kinase, type II, alpha|phosphatidylinositol-5-phosphate 4-kinase type-2 alpha|ptdIns(4)P-5-kinase C isoform|ptdIns(5)P-4-kinase isoform 2-alpha|type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
Swissprots	P48426 B4DGX2 D3DRV1 P53807 Q5VUX3 B0YJ66
Accessions	ACA06044 ACA06045 EAW86140 EAW86141 P48426 AK023329 AK294817 BAG57933 AK294867 BAG57970 BC018034 AAH18034 DB504104 S78798 AAB35041 U14957 AAA64835 XM_006717450 XP_006717513 XM_011519494 XP_011517796 XM_011519495 XP_011517797 XM_011519496 XP_011517798 XM_011519497 XP_011517799 NM_005028 NP_005019
Function	Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269|PubMed:18364242}.
Subcellular Location	Cell membrane {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.
Tissue Specificity	Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}.
Top Pathways	Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PIP5K2 alpha full length protein - ab125572 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PIP5K2 alpha peptide - ab23205 from Abcam Category Peptide Species Human

Human PIP5K2 alpha protein fragment - ab127255 from Abcam Category Protein Source E. coli Species Human

PIP4K2A / PIPK Antibody Blocking Peptide - LS-E20581 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIP4K2A / PIPK Antibody Blocking Peptide - LS-E20580 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIP4K2A / PIPK Antibody Blocking Peptide - LS-E9450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIP4K2A / PIPK Antibody Blocking Peptide - LS-E9449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIP5K2 alpha Protein - H00005305-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PIP5K2 alpha Protein - H00005305-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIP5K2 alpha Peptide - P3024 from Novus Biologicals Category Peptide Species Human

PIP5K2 alpha Peptide - P3023 from Novus Biologicals Category Peptide Species Human

PIP4K2-Alpha-PIP4K2A-Antibody-C-term-Blocking-peptide - BP8041b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP4K2-Alpha-PIP4K2A-Antibody-N-term-Blocking-peptide - BP8041a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP4K2A Blocking Peptide - 33R-2661 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIP4K2A Blocking Peptide - 33R-3909 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIP4K2A / PIP5K2A - H00005305-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

PIP4K2A / PIP5K2A - H00005305-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIP4K2A / PIP5K2A - H00005305-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIP4K2A fusion protein - Ag3152 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PIP4K2A, GST-tagged - PIP4K2A-1724H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PIP4K2A (Active), GST-tagged - PIP4K2A-1458H from Creative Biomart Category Protein Source Sf9 Cells Species Human

PIP4K2α Protein, active, 10 µg - 14-901 from EMD Millipore Category Protein Prices $730.00 Sizes 10 µg also available in 250μg size as catalog # 14-901m - call for pricing and availability. Source Expressed by baculovirus in Sf21 insect cells

PIP4K2α Protein, active, 250 µg - 14-901M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-901) and in bulk (cat# 14-901-K) Source Expressed by baculovirus in Sf21 insect cells

Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha(PIP4K2A) - CSB-YP018022HU CSB-EP018022HU CSB-BP018022HU CSB-MP018022HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIP4K2A Protein - abx164357 from Abbexa Category Protein Species Human, Mouse, Rat

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