| Gene Symbol |
RRM2B
|
| Entrez Gene |
101865579
|
| Alt Symbol |
-
|
| Species |
Monkey
|
| Gene Type |
protein-coding
|
| Description |
ribonucleotide reductase M2 B (TP53 inducible)
|
| Other Description |
Ribonucleoside-diphosphate reductase subunit M2 B
|
| Swissprots |
Q4R741
|
| Accessions |
EHH64346 Q4R741 AB168988 BAE01083 XM_005563834 XP_005563891
|
| Function |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from cytoplasm to nucleus in response to DNA damage. {ECO:0000250}.
|
| Top Pathways |
p53 signaling pathway, Purine metabolism, Glutathione metabolism, Pyrimidine metabolism
|