| Gene Symbol |
LDLR
|
| Entrez Gene |
100009086
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor
|
| Other Description |
LDL receptor|low-density lipoprotein receptor
|
| Swissprots |
P20063
|
| Accessions |
P20063 JX679211 AFX60885 M11501 AAA31383 NM_001278865 NP_001265794
|
| Function |
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Cell surface {ECO:0000250}. Lysosome {ECO:0000250}. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 (By similarity). {ECO:0000250}.
|
| Top Pathways |
Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis
|