FMN2
| Gene Symbol | FMN2 |
|---|---|
| Entrez Gene | 56776 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | formin 2 |
| Other Description | formin-2 |
| Swissprots | Q59GF6 Q9NZ55 Q5VU37 B0QZA7 Q9NZ56 B4DP05 |
| Accessions | EAW70082 Q9NZ56 AB209153 BAD92390 AF218941 AAF72884 AF218942 AAF72885 AF225426 AAG09728 AK297716 BAG60071 AK297755 BAH12659 AK298141 BAG60417 BC014364 AAH14364 BC112335 AAI12336 BC112361 AAI12362 DB476003 DN990332 XM_005273200 XP_005273257 XM_011544237 XP_011542539 XR_949151 NM_001305424 NP_001292353 NM_020066 NP_064450 |
| Function | Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress- induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation. {ECO:0000250, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus, nucleolus. Note=Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed almost exclusively in the developing and mature central nervous system. {ECO:0000269|PubMed:10781961}. |
| Top Pathways | Dorso-ventral axis formation |
Formin 2 CRISPR/Cas9 KO Plasmid (h) - sc-404641 from Santa Cruz Biotechnology
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Formin 2 HDR Plasmid (h) - sc-404641-HDR from Santa Cruz Biotechnology
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Formin 2 Double Nickase Plasmid (h) - sc-404641-NIC from Santa Cruz Biotechnology
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Formin 2 Double Nickase Plasmid (h2) - sc-404641-NIC-2 from Santa Cruz Biotechnology
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Formin 2 CRISPR Activation Plasmid (h) - sc-404641-ACT from Santa Cruz Biotechnology
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Formin 2 CRISPR Activation Plasmid (h2) - sc-404641-ACT-2 from Santa Cruz Biotechnology
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Formin 2 Lentiviral Activation Particles (h) - sc-404641-LAC from Santa Cruz Biotechnology
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Formin 2 Lentiviral Activation Particles (h2) - sc-404641-LAC-2 from Santa Cruz Biotechnology
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Formin 2 siRNA (h) - sc-43765 from Santa Cruz Biotechnology
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Formin 2 shRNA Plasmid (h) - sc-43765-SH from Santa Cruz Biotechnology
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Formin 2 shRNA (h) Lentiviral Particles - sc-43765-V from Santa Cruz Biotechnology
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FMN2 RNAi - H00056776-R01 from Novus Biologicals
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MISSION® esiRNA - EHU098461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8836 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8836 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08227 from Sigma-Aldrich
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FMN2 siRNA (Human) - CRJ1180 from Cohesion Biosciences
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FMN2 - MBS8232324 from MyBioSource
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shRNA set against Human FMN2 (NM_020066.4) - SHH295853 from Creative biogene
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shRNA set against Human FMN2(NM_020066.4) - SHH063749 from Creative biogene
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Human FMN2 siRNA - orb271681 from Biorbyt
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FMN2 shRNA Plasmid (Human) - CHJ1180 from Cohesion Biosciences
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FMN2 miRNA 3'UTR clone - MiUTR1H-03776 from Creative biogene
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