FMN2

Gene Symbol FMN2
Entrez Gene 56776
Alt Symbol -
Species Human
Gene Type protein-coding
Description formin 2
Other Description formin-2
Swissprots Q59GF6 Q9NZ55 Q5VU37 B0QZA7 Q9NZ56 B4DP05
Accessions EAW70082 Q9NZ56 AB209153 BAD92390 AF218941 AAF72884 AF218942 AAF72885 AF225426 AAG09728 AK297716 BAG60071 AK297755 BAH12659 AK298141 BAG60417 BC014364 AAH14364 BC112335 AAI12336 BC112361 AAI12362 DB476003 DN990332 XM_005273200 XP_005273257 XM_011544237 XP_011542539 XR_949151 NM_001305424 NP_001292353 NM_020066 NP_064450
Function Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress- induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation. {ECO:0000250, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502}.
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus, nucleolus. Note=Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). {ECO:0000250}.
Tissue Specificity Expressed almost exclusively in the developing and mature central nervous system. {ECO:0000269|PubMed:10781961}.
Top Pathways Dorso-ventral axis formation

Formin 2 (H-100) - sc-50398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Formin 2 (H-100): sc-50398. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic and membrane staining of glandular cells.

Formin 2 (H-65) - sc-50399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Formin 2 (K-18) - sc-22735 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FMN2 antibody - ab72052 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FMN2 antibody (ab72052) at 0.25 µg/mlLane 1 : human brain lysateLane 2 : human brain lysate with immunising peptide

Anti-FMN2 antibody - ab72421 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of FMN2 in paraffin-embedded formalin-fixed human uterus tissue using an isotype control (top) and ab72421 (bottom) at 1:100.

Anti-FMN2 antibody - C-terminal - ab194500 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-FMN2 antibody - C-terminal (ab194500) at 1/500 dilution + K562 cell lysate at 50 µgdeveloped using the ECL technique

Anti-FMN2 / Formin 2 Antibody (aa1541-1590) - LS-C119981 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using FMN2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FMN2 / Formin 2 Antibody (clone 1C2) - LS-C139358 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2
Detection limit for recombinant GST tagged FMN2 is 0.3 ng/ml as a capture antibody.

Anti-FMN2 / Formin 2 Antibody (aa168-186) - LS-C148428 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of FMN2 in paraffin-embedded formalin-fixed human uterus tissue using an isotype control (top) and LS-C148428 (bottom) at 1:100.

Anti-FMN2 / Formin 2 Antibody (aa657-674) - LS-C148448 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of FMN2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148448 at 0.25 ug/ml.

FMN2 Antibody - NBP2-24615 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FMN2 Antibody [NBP2-24615] - Analysis of FMN2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using NBP2-24615 at 0.25 ug/ml.

FMN2 Antibody - NBP2-23745 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FMN2 Antibody [NBP2-23745] - analysis of FMN2 in paraffin-embedded formalin-fixed human uterus tissue using an isotype control (top) and this antibody (bottom) at 1:100.

FMN2 Antibody - NBP1-86510 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: FMN2 Antibody [NBP1-86510] - Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in goblet cells.

FMN2 Antibody - H00056776-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: FMN2 Antibody [H00056776-A01] - Analysis of FMN2 expression in K-562 (Cat # L009V1).

FMN2 Antibody (4B8) - H00056776-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B8

Rabbit Anti-FMN2 Polyclonal Antibody - bs-7748R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-FMN2 Polyclonal Antibody, Unconjugated (bs-7748R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-FMN2 antibody produced in rabbit - HPA004937 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FMN2: <B>Cat. No. HPA004937</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in goblet cells.

Monoclonal Anti-FMN2, (C-terminal) antibody produced in mouse - SAB1405193 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2
<B>Immunoblotting</B><BR/>Monoclonal Anti-FMN2: <B>Cat. No. SAB1405193</B>: Antibody concentration: 1 μg/mL. Specific band of ~37 kDa using immunogen protein lysate.

Monoclonal Anti-FMN2 antibody produced in mouse - WH0056776M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B8
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-FMN2, <B>Cat. No. WH0056776M2</B>: the detection limit for recombinant GST tagged FMN2 is approximately 0.3ng/mL.

Anti-FMN2, C-Terminal antibody produced in rabbit - SAB4502431 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FMN2, C-Terminal: <B>Cat. No. SAB4502431</B>: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-FMN2, C-Terminal antibody. Cells on the left were treated with the Anti-FMN2, C-Terminal antibody. Cells on the right (negative control) were treated with both Anti-FMN2, C-Terminal antibody and the synthesized immunogen peptide.

FMN2-Antibody-monoclonal-M02 - AT2076a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B8
Western Blot analysis of FMN2 expression in transfected 293T cell line by FMN2 monoclonal antibody (M02), clone 4B8.Lane 1: FMN2 transfected lysate (Predicted MW: 11.11 KDa).Lane 2: Non-transfected lysate.

FMN2 Antibody (OAAF03676) - OAAF03676 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti -FMN2 (Formin 2, Formin-2) - 126902 from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 4B8

Anti -FMN2 (Formin 2, Formin-2) (AP) - 126902-AP from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 4B8

Anti -FMN2 (Formin 2, Formin-2) (Biotin) - 126902-Biotin from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 4B8
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