Gene Symbol | ASAH1 |
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Entrez Gene | 427 |
Alt Symbol | AC, ACDase, ASAH, PHP, PHP32, SMAPME |
Species | Human |
Gene Type | protein-coding |
Description | N-acylsphingosine amidohydrolase (acid ceramidase) 1 |
Other Description | acid CDase|acid ceramidase|acylsphingosine deacylase|putative 32 kDa heart protein |
Swissprots | E9PDS0 Q6W898 Q13510 Q96AS2 |
Accessions | AAF91230 BAG12319 BAG12320 BAG12321 BAG12322 BAG12323 BAG12324 BAG12325 BAG12326 BAG12327 BAG12328 BAG12329 BAG12330 BAG12331 BAG12332 BAG12333 BAG12334 BAG12335 BAG12336 BAG12337 BAG12338 BAG12339 BAG12340 BAG12341 BAG12342 BAG12343 BAG12344 BAG12345 BAG12346 BAG12347 BAG12348 BAG12349 BAG12350 BAG12351 BAG12352 BAG12353 BAG12354 BAG12355 BAG12356 BAG12357 BAG12358 BAG12359 BAG12360 BAG12361 BAG12362 BAG12363 BAG12364 BAG12365 BAG12366 BAG12367 BAG12368 BAG12369 BAG12370 BAG12371 BAG12372 BAG12373 BAG12374 BAG12375 BAG12376 BAG12377 EAW63791 EAW63792 EAW63793 EAW63794 EAW63795 Q13510 AK025211 BAB15085 AK025732 AK098299 BAG53608 AK222780 BAD96500 AK289481 BAF82170 AY305384 AAQ75550 BC016481 AAH16481 BC016828 AAH16828 BC035453 BG714023 BU633536 CB216602 DA260852 DA306573 DB561177 DQ891071 ABM81997 DQ894254 ABM85180 H78830 U47674 AAC73009 U70063 AAC50907 XM_005273504 XP_005273561 NM_001127505 NP_001120977 NM_004315 NP_004306 NM_177924 NP_808592 |
Function | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. |
Subcellular Location | Lysosome. |
Tissue Specificity | Broadly expressed with highest expression in heart. |
Top Pathways | Lysosome, Sphingolipid signaling pathway, Sphingolipid metabolism |
Acid Ceramidase CRISPR/Cas9 KO Plasmid (h) - sc-401495 from Santa Cruz Biotechnology
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Acid Ceramidase HDR Plasmid (h) - sc-401495-HDR from Santa Cruz Biotechnology
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Acid Ceramidase Double Nickase Plasmid (h) - sc-401495-NIC from Santa Cruz Biotechnology
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Acid Ceramidase Double Nickase Plasmid (h2) - sc-401495-NIC-2 from Santa Cruz Biotechnology
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Acid Ceramidase CRISPR Activation Plasmid (h) - sc-401495-ACT from Santa Cruz Biotechnology
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Acid Ceramidase CRISPR Activation Plasmid (h2) - sc-401495-ACT-2 from Santa Cruz Biotechnology
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Acid Ceramidase Lentiviral Activation Particles (h) - sc-401495-LAC from Santa Cruz Biotechnology
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Acid Ceramidase Lentiviral Activation Particles (h2) - sc-401495-LAC-2 from Santa Cruz Biotechnology
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Acid Ceramidase siRNA (h) - sc-105032 from Santa Cruz Biotechnology
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Acid Ceramidase shRNA Plasmid (h) - sc-105032-SH from Santa Cruz Biotechnology
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Acid Ceramidase shRNA (h) Lentiviral Particles - sc-105032-V from Santa Cruz Biotechnology
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ASAH1 RNAi - H00000427-R01 from Novus Biologicals
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ASAH1 RNAi - H00000427-R02 from Novus Biologicals
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MISSION® esiRNA - EHU064111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3558 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3558 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07856 from Sigma-Aldrich
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ASAH1 siRNA (Human) - CRH0308 from Cohesion Biosciences
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ASAH1 - MBS8217670 from MyBioSource
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shRNA set against Human ASAH1 (NM_004315.4) - SHH241058 from Creative biogene
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ASAH1 shRNA Plasmid (Human) - CHH0308 from Cohesion Biosciences
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ASAH1 miRNA 3'UTR clone - MiUTR3H-12910 from Creative biogene
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ASAH1 miRNA 3'UTR clone - MiUTR3H-12911 from Creative biogene
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ASAH1 miRNA 3'UTR clone - MiUTR3H-12912 from Creative biogene
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