Gene Symbol | Hexa |
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Entrez Gene | 15211 |
Alt Symbol | Hex-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | hexosaminidase A |
Other Description | N-acetyl-beta-glucosaminidase subunit alpha|beta-N-acetylhexosaminidase subunit alpha|beta-hexosaminidase subunit alpha|hexosaminidase subunit A |
Swissprots | P29416 Q64246 Q91XG3 |
Accessions | AAA18777 AAC53246 EDL25971 P29416 AK075895 BAC36036 AK075911 BAC36049 AK080777 BAC38018 AK144168 BAE25744 AK150444 BAE29566 AK151960 BAE30831 AK159091 BAE34808 AK159814 BAE35394 AK159890 BAE35457 AK160112 BAE35636 AK167013 BAE39189 AK168186 BAE40146 AK170903 AK179213 AK197174 AK204255 AK211327 AK213356 AK218113 BC010755 AAH10755 U07631 AAA18775 X64331 CAA45615 XR_379397 NM_010421 NP_034551 |
Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. |
Subcellular Location | Lysosome. |
Tissue Specificity | Ubiquitous. Most abundant in testis, adrenal, epididymis and heart. Low levels seen in the liver. {ECO:0000269|PubMed:7896264}. |
Top Pathways | Lysosome, Amino sugar and nucleotide sugar metabolism, Glycosphingolipid biosynthesis - globo series, Other glycan degradation, Glycosaminoglycan degradation |
HEXA CRISPR/Cas9 KO Plasmid (m) - sc-420837 from Santa Cruz Biotechnology
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HEXA HDR Plasmid (m) - sc-420837-HDR from Santa Cruz Biotechnology
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HEXA Double Nickase Plasmid (m) - sc-420837-NIC from Santa Cruz Biotechnology
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HEXA Double Nickase Plasmid (m2) - sc-420837-NIC-2 from Santa Cruz Biotechnology
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HEXA CRISPR Activation Plasmid (m) - sc-420837-ACT from Santa Cruz Biotechnology
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HEXA CRISPR Activation Plasmid (m2) - sc-420837-ACT-2 from Santa Cruz Biotechnology
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HEXA Lentiviral Activation Particles (m) - sc-420837-LAC from Santa Cruz Biotechnology
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HEXA Lentiviral Activation Particles (m2) - sc-420837-LAC-2 from Santa Cruz Biotechnology
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HEXA siRNA (m) - sc-60784 from Santa Cruz Biotechnology
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HEXA shRNA Plasmid (m) - sc-60784-SH from Santa Cruz Biotechnology
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HEXA shRNA (m) Lentiviral Particles - sc-60784-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33199 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33199 from Sigma-Aldrich
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HEXA siRNA (Mouse) - CRM1810 from Cohesion Biosciences
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HEXA - MBS8230805 from MyBioSource
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shRNA set against Mouse HEXA (NM_010421.4) - SHH311769 from Creative biogene
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shRNA set against Mouse Hexa(NM_010421.4) - SHH119117 from Creative biogene
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HEXA shRNA Plasmid (Mouse) - CHM1810 from Cohesion Biosciences
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HEXA miRNA 3'UTR clone - MiUTR1M-05607 from Creative biogene
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