| Gene Symbol |
VIPR2
|
| Entrez Gene |
7434
|
| Alt Symbol |
C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vasoactive intestinal peptide receptor 2
|
| Other Description |
PACAP type III receptor|VIP and PACAP receptor 2|helodermin-preferring VIP receptor|pituitary adenylate cyclase-activating polypeptide type III receptor|vasoactive intestinal polypeptide receptor 2
|
| Swissprots |
P41587 Q13053 Q6ZN22 Q9UCW0 Q53Y09 Q15870
|
| Accessions |
AAC09171 AAC41756 CAB41899 EAL23936 EAL23937 EAX04596 P41587 AK131406 BAD18553 AK308955 AK310386 BC010569 AAH10569 BT007118 AAP35782 CA449700 DQ890571 ABM92188 DQ893732 ABM84658 KJ534960 AHW56600 KJ534961 AHW56601 KJ534970 AHW56610 L36566 AAC37569 U18810 AAC50872 X95097 CAA64474 XM_005249561 XP_005249618 XM_006716107 XP_006716170 XM_006716108 XP_006716171 XM_011516550 XP_011514852 XM_011516551 XP_011514853 XM_011516552 XP_011514854 XR_242047 NM_001304522 NP_001291451 NM_001308259 NP_001295188 NM_003382 NP_003373 NR_130758
|
| Function |
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. {ECO:0000269|PubMed:8926282}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in CD4+ T-cells, but not in CD8+ T- cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78. {ECO:0000269|PubMed:8926282}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: VPAC2 Overexpression Lysate (Adult Normal) [NBP2-04248] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VPAC2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4177_VPAC2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04248-img0001.jpg)