| Gene Symbol |
Cdkn1c
|
| Entrez Gene |
12577
|
| Alt Symbol |
AL024410, CDKI, Kip2, p57(kip2), p57Kip2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase inhibitor 1C (P57)
|
| Other Description |
cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor p57
|
| Swissprots |
P49919 G3UW61
|
| Accessions |
AAF00983 CAC16402 EDL18207 EDL18208 P49919 AA986859 AK003959 AK077844 BAC37031 AK132278 BC005412 AAH05412 CJ175313 U20553 AAC52186 U22399 AAA85096 XM_006508467 XP_006508530 XM_006508468 XP_006508531 XM_006508469 XP_006508532 XM_006508470 XP_006508533 XM_006508471 XP_006508534 NM_001161624 NP_001155096 NM_009876 NP_034006
|
| Function |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
|
| Top Pathways |
Cell cycle
|