Gene Symbol | Cdkn1c |
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Entrez Gene | 12577 |
Alt Symbol | AL024410, CDKI, Kip2, p57(kip2), p57Kip2 |
Species | Mouse |
Gene Type | protein-coding |
Description | cyclin-dependent kinase inhibitor 1C (P57) |
Other Description | cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor p57 |
Swissprots | P49919 G3UW61 |
Accessions | AAF00983 CAC16402 EDL18207 EDL18208 P49919 AA986859 AK003959 AK077844 BAC37031 AK132278 BC005412 AAH05412 CJ175313 U20553 AAC52186 U22399 AAA85096 XM_006508467 XP_006508530 XM_006508468 XP_006508531 XM_006508469 XP_006508532 XM_006508470 XP_006508533 XM_006508471 XP_006508534 NM_001161624 NP_001155096 NM_009876 NP_034006 |
Function | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. |
Top Pathways | Cell cycle |
p57 CRISPR/Cas9 KO Plasmid (m) - sc-419609 from Santa Cruz Biotechnology
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p57 HDR Plasmid (m) - sc-419609-HDR from Santa Cruz Biotechnology
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p57 Double Nickase Plasmid (m) - sc-419609-NIC from Santa Cruz Biotechnology
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p57 Double Nickase Plasmid (m2) - sc-419609-NIC-2 from Santa Cruz Biotechnology
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p57 CRISPR Activation Plasmid (m) - sc-419609-ACT from Santa Cruz Biotechnology
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p57 CRISPR Activation Plasmid (m2) - sc-419609-ACT-2 from Santa Cruz Biotechnology
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p57 Lentiviral Activation Particles (m) - sc-419609-LAC from Santa Cruz Biotechnology
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p57 Lentiviral Activation Particles (m2) - sc-419609-LAC-2 from Santa Cruz Biotechnology
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p57 siRNA (m) - sc-37621 from Santa Cruz Biotechnology
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Kip2 p57 shRNA Plasmid (m) - sc-37621-SH from Santa Cruz Biotechnology
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Kip2 p57 shRNA (m) Lentiviral Particles - sc-37621-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU028861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28506 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28506 from Sigma-Aldrich
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CDKN1C siRNA (Mouse) - CRM0648 from Cohesion Biosciences
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CDKN1C - MBS8204989 from MyBioSource
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shRNA set against Mouse CDKN1C (NM_009876.4) - SHH260837 from Creative biogene
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CDKN1C shRNA Plasmid (Mouse) - CHM0648 from Cohesion Biosciences
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