Gene Symbol | HTR3D |
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Entrez Gene | 200909 |
Alt Symbol | 5HT3D |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic |
Other Description | 5-hydroxytryptamine (serotonin) receptor 3 family member D|5-hydroxytryptamine receptor 3 subunit D|5-hydroxytryptamine receptor 3D|serotonin 5-HT-3D receptor|serotonin receptor 3D |
Swissprots | J3QT78 Q495N5 Q7Z6B3 Q495N6 C9J2I6 Q70Z44 |
Accessions | Q70Z44 AJ437318 CAD24817 AY159812 AAO38166 BC101090 AAI01091 BC101091 AAI01092 BK001746 NM_001145143 NP_001138615 NM_001163646 NP_001157118 NM_182537 NP_872343 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000269|PubMed:17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
Tissue Specificity | Expressed in liver, as well as fetal and adult colon and kidney. {ECO:0000269|PubMed:12801637}. |
HTR3D CRISPR/Cas9 KO Plasmid (h) - sc-415002 from Santa Cruz Biotechnology
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HTR3D HDR Plasmid (h) - sc-415002-HDR from Santa Cruz Biotechnology
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HTR3D Double Nickase Plasmid (h) - sc-415002-NIC from Santa Cruz Biotechnology
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HTR3D Double Nickase Plasmid (h2) - sc-415002-NIC-2 from Santa Cruz Biotechnology
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HTR3D CRISPR Activation Plasmid (h) - sc-415002-ACT from Santa Cruz Biotechnology
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HTR3D CRISPR Activation Plasmid (h2) - sc-415002-ACT-2 from Santa Cruz Biotechnology
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HTR3D Lentiviral Activation Particles (h) - sc-415002-LAC from Santa Cruz Biotechnology
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HTR3D Lentiviral Activation Particles (h2) - sc-415002-LAC-2 from Santa Cruz Biotechnology
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HTR3D siRNA (h) - sc-78056 from Santa Cruz Biotechnology
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HTR3D shRNA Plasmid (h) - sc-78056-SH from Santa Cruz Biotechnology
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HTR3D shRNA (h) Lentiviral Particles - sc-78056-V from Santa Cruz Biotechnology
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5-HT3D RNAi - H00200909-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10396 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10396 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03869 from Sigma-Aldrich
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HTR3D siRNA (Human) - CRJ6267 from Cohesion Biosciences
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HTR3D - MBS8204243 from MyBioSource
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shRNA set against Human HTR3D (NM_182537.2) - SHH315977 from Creative biogene
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HTR3D shRNA Plasmid (Human) - CHJ6267 from Cohesion Biosciences
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HTR3D miRNA 3'UTR clone - MiUTR1H-04756 from Creative biogene
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