| Gene Symbol |
ZC3H12A
|
| Entrez Gene |
80149
|
| Alt Symbol |
MCPIP, MCPIP1, dJ423B22.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger CCCH-type containing 12A
|
| Other Description |
MCP induced protein 1|MCP-1 treatment-induced protein|MCP-induced protein 1|ribonuclease ZC3H12A|zinc finger CCCH domain-containing protein 12A
|
| Swissprots |
Q9H5P1 D3DPT0 Q5D1E8 Q6I9Z1
|
| Accessions |
EAX07346 EAX07347 EAX07348 Q5D1E8 AK026884 BAB15581 AK093343 BAG52695 AY920403 AAX14017 BC005001 AAH05001 CR457364 CAG33645 CR995909 DA601465 FJ695517 ACN39723 XM_006710925 XP_006710988 XM_006710926 XP_006710989 XM_011542193 XP_011540495 XM_011542194 XP_011540496 XM_011542195 XP_011540497 XM_011542196 XP_011540498 XM_011542197 XP_011540499 XM_011542198 XP_011540500 NM_025079 NP_079355
|
| Function |
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. {ECO:0000250, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:22561375}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:16574901}.
|
![Western Blot: ZC3H12A Overexpression Lysate (Adult Normal) [NBP2-06242] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZC3H12A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6642_ZC3H12A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06242-img0001.jpg)