| Gene Symbol |
KRTAP1-3
|
| Entrez Gene |
81850
|
| Alt Symbol |
KAP1.2, KAP1.3, KAP1.6, KAP1.8A, KAP1.8B, KAP1.9, KRTAP1.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 1-3
|
| Other Description |
keratin associated protein 1.6|keratin-associated protein 1-3|keratin-associated protein 1.8|keratin-associated protein 1.9
|
| Swissprots |
Q8IUG1 Q9BYS2 Q8IUG0 Q07628
|
| Accessions |
BAC15620 EAW60698 Q8IUG1 AJ406927 CAC27566 BC069161 AAH69161 BC101150 AAI01151 BC101151 AAI01152 BC101152 AAI01153 BC101153 AAI01154 NM_030966 NP_112228
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269|PubMed:11279113}.
|