FBXW5

Gene Symbol FBXW5
Entrez Gene 54461
Alt Symbol Fbw5
Species Human
Gene Type protein-coding
Description F-box and WD repeat domain containing 5
Other Description F-box and WD-40 domain-containing protein 5|F-box/WD repeat-containing protein 5|WD repeat-containing F-box protein FBW5
Swissprots Q96GJ6 Q9HBQ6 Q5SPZ8 B2RDZ6 Q5SQ04 Q9BSU8 Q969U6 Q5SPZ9 Q5SQ02 Q9H6A8 Q8WY79 Q9NSZ3 Q5SQ00 Q5SQ03 Q59ET5
Accessions EAW88307 EAW88308 EAW88309 EAW88310 EAW88311 EAW88312 EAW88313 EAW88314 EAW88315 Q969U6 AB209726 BAD92963 AF217998 AAG17240 AF258569 AAG23772 AK026081 BAB15354 AK315738 BAG38093 AL137631 CAB70851 BC000850 AAH00850 BC004541 AAH04541 BC009429 AAH09429 BC014130 AAH14130 BC014297 AAH14297 BC031100 BC035355 BI829307 CF132404 DB460097 EC577580 JF432249 ADZ15466 XM_005266089 XP_005266146 XM_011518789 XP_011517091 XR_929811 NM_018998 NP_061871 NM_178225 NM_178226
Function Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21725316}.

FBXW5 (N-13) - sc-160328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBXW5 (N-13): sc-160328. Western blot analysis of FBXW5 expression in U-2 OS (A), Jurkat (B), Ramos (C) and K-562 (D) whole cell lysates and rat skeletal muscle (E) and mouse heart (F) tissue extracts.

FBXW5 (T-16) - sc-160329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBXW5 (T-16): sc-160329. Western blot analysis of FBXW5 expression in rat heart tissue extract.

FBXW5 (H-264) - sc-366618 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBXW5 (H-264): sc-366618. Western blot analysis of FBXW5 expression in Jurkat (A), Ramos (B) and K-562 (C) whole cell lysates.

Anti-FBXW5 antibody - ab154347 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXW5 antibody (ab154347) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-FBXW5 antibody - ab174502 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXW5 antibody (ab174502) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-FBXW5 antibody - ab67865 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FBXW5 antibody (ab67865) at 1/500 dilutionLane 1 : FBXW5 fragment transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutionObserved band size : 16 kDa (why is the actual band size different from the predicted?)

Anti-FBXW5 antibody - ab186893 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXW5 antibody (ab186893) at 1 µg/ml + MDA-MB-435S whole cell lysate at 10 µg

Anti-FBXW5 Antibody (aa324-350, AP) - LS-C259358 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350, APC) - LS-C259359 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350, Azide-free, HRP) - LS-C259362 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350, FITC) - LS-C259361 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350, Biotin) - LS-C259360 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody - LS-C307505 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350, PE) - LS-C259363 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa324-350) - LS-C321333 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 Antibody (aa121-170) - LS-C206218 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBXW5 antibody Western Blot of MDA-MB-435S. Antibody dilution: 1 ug/ml.

Anti-FBXW5 Antibody (aa324-350) - LS-C157746 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FBXW5 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The FBXW5 antibody detected the FBXW5 protein (arrow).

FBXW5 Antibody - NBP2-16455 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FBXW5 Antibody - NBP1-91892 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FBXW5 Antibody - H00054461-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: FBXW5 Antibody [H00054461-B01P] - Analysis of FBXW5 expression in transfected 293T cell line by FBXW5 polyclonal antibody. Lane 1: FBXW5 transfected lysate(17.49 KDa). Lane 2: Non-transfected lysate.

FBXW5 Polyclonal Antibody - bs-9083R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXW5 antibody produced in mouse - SAB1407546 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FBXW5: <B>Cat. No. SAB1407546</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~17.5 kDa using FBXW5 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-FBXW5 antibody produced in rabbit - HPA046615 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FBXW5: <B>Cat. No. HPA046615</B>: Immunohistochemical staining of human stomach, upper shows strong membranous and cytoplasmic positivity in glandular cells.

Anti-FBXW5 antibody produced in rabbit - SAB2701451 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FBXW5: <B>Cat. No. SAB2701451</B>: Immunohistochemical analysis of paraffin-embedded Colon ca, using FBXW5 antibody at 1:500 dilution.

FBXW5 Antibody - N-terminal region (ARP73235_P050) - ARP73235_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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