| Gene Symbol |
FBXW5
|
| Entrez Gene |
54461
|
| Alt Symbol |
Fbw5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and WD repeat domain containing 5
|
| Other Description |
F-box and WD-40 domain-containing protein 5|F-box/WD repeat-containing protein 5|WD repeat-containing F-box protein FBW5
|
| Swissprots |
Q96GJ6 Q9HBQ6 Q5SPZ8 B2RDZ6 Q5SQ04 Q9BSU8 Q969U6 Q5SPZ9 Q5SQ02 Q9H6A8 Q8WY79 Q9NSZ3 Q5SQ00 Q5SQ03 Q59ET5
|
| Accessions |
EAW88307 EAW88308 EAW88309 EAW88310 EAW88311 EAW88312 EAW88313 EAW88314 EAW88315 Q969U6 AB209726 BAD92963 AF217998 AAG17240 AF258569 AAG23772 AK026081 BAB15354 AK315738 BAG38093 AL137631 CAB70851 BC000850 AAH00850 BC004541 AAH04541 BC009429 AAH09429 BC014130 AAH14130 BC014297 AAH14297 BC031100 BC035355 BI829307 CF132404 DB460097 EC577580 JF432249 ADZ15466 XM_005266089 XP_005266146 XM_011518789 XP_011517091 XR_929811 NM_018998 NP_061871 NM_178225 NM_178226
|
| Function |
Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21725316}.
|