| Gene Symbol |
WASH1
|
| Entrez Gene |
100287171
|
| Alt Symbol |
FAM39E, WASH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WAS protein family homolog 1
|
| Other Description |
CXYorf1-like protein on chromosome 9|FLJ00075 protein|family with sequence similarity 39, member E
|
| Swissprots |
A8K0Z3
|
| Accessions |
A8K0Z3 ABX71510 AK024448 BAB15738 AK024481 BAB15771 AK289708 BAF82397 AK309568 BC014406 BC063893 BC094860 BC156859 AAI56860 BC160141 AAI60141 BM970740 CN404407 XM_011517658 XP_011515960 XM_011517659 XP_011515961 XM_011517660 XP_011515962 XM_011517661 XP_011515963 XM_011517662 XP_011515964 XM_011517663 XP_011515965 XM_011517664 XP_011515966 XM_011517665 XP_011515967 XM_011517666 XP_011515968 XM_011517667 XP_011515969 XM_011517668 XP_011515970 XM_011517669 XP_011515971 XM_011517670 XP_011515972 XM_011517671 XP_011515973 XM_011517672 XP_011515974 XR_929142 XR_929143 NM_182905 NP_878908
|
| Function |
Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Its assembly in the WASH core complex seems to inhibit its NPF activity and via FAM21 is required for its membrane targeting (PubMed:20498093). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility
|
| Subcellular Location |
Early endosome membrane {ECO:0000269|PubMed:19922874}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Late endosome {ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:24344185}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with FAM21 (PubMed:19922874). Localizes to MMP14- positive late endosomes and transiently to invadipodia (PubMed:24344185). Localized to Salmonella typhimurium entry sites (By similarity). {ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:24344185}.
|