| Gene Symbol |
CMA1
|
| Entrez Gene |
1215
|
| Alt Symbol |
CYH, MCT1, chymase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chymase 1, mast cell
|
| Other Description |
alpha-chymase|chymase|chymase 1 preproprotein transcript E|chymase 1 preproprotein transcript I|chymase, heart|chymase, mast cell|mast cell protease I
|
| Swissprots |
Q9UDH5 Q3SY36 Q16018 Q3SY37 B5BUM8 P23946
|
| Accessions |
AAA52020 AAA52021 CAA41796 EAW66007 P23946 AB451464 BAG70278 BC069110 AAH69110 BC069370 AAH69370 BC069490 AAH69490 BC103974 AAI03975 BC103975 AAI03976 DQ082727 AAZ06432 DQ082729 AAZ06434 HY275608 M69136 AAA52019 S61334 AAB26828 XM_011536394 XP_011534696 NM_001308083 NP_001295012 NM_001836 NP_001827
|
| Function |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
|
| Subcellular Location |
Secreted. Cytoplasmic granule. Note=Mast cell granules.
|
| Tissue Specificity |
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269|PubMed:8144971}.
|
| Top Pathways |
Renin-angiotensin system
|
![Western Blot: Mast Cell Chymase Overexpression Lysate (Adult Normal) [NBL1-09293] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Mast Cell Chymase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4582_Mast%2520Cell%2520Chymase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09293-img0002.jpg)