| Gene Symbol |
Ier3
|
| Entrez Gene |
15937
|
| Alt Symbol |
AI663993, IEX-1, cI-3, gly96
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
immediate early response 3
|
| Other Description |
cAMP inducible gene 3|immediate early protein GLY96|immediate early response 3 protein|radiation-inducible immediate-early gene IEX-1
|
| Swissprots |
P46694
|
| Accessions |
AAO39405 EDL23233 EDL23234 P46694 AK003466 AK051003 BAC34493 AK170477 BAE41821 BC006950 AAH06950 CT010247 CAJ18455 CT010271 CAJ18479 X67644 NM_133662 NP_598423
|
| Function |
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. {ECO:0000250, ECO:0000269|PubMed:22565310}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in the lung, testes and the uterus.
|