| Gene Symbol |
ZFP91
|
| Entrez Gene |
80829
|
| Alt Symbol |
DMS-8, DSM-8, FKSG11, PZF, ZFP-91, ZNF757
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ZFP91 zinc finger protein
|
| Other Description |
E3 ubiquitin-protein ligase ZFP91|drug resistance-associated sequence in melanoma 8|penta zinc finger protein|zinc finger protein 757|zinc finger protein 91 homolog|zinc finger protein homologous to Zfp91 in mouse
|
| Swissprots |
Q96JP4 A8MSG7 Q96JP5 Q96QA3 Q86V47 A6NHC4
|
| Accessions |
EAW73811 EAW73813 EAW73816 EAW73817 EAW73818 Q96JP5 AB056107 BAB63373 AF305825 AAK55528 AF310246 AAL09963 AI687439 AJ270692 AK025502 AK295700 BAG58548 BC051743 AAH51743 BP219969 NM_001197051 NP_001183980 NM_053023 NP_444251
|
| Function |
Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12738986}.
|
| Tissue Specificity |
Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
|