Gene Symbol | ZFP91 |
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Entrez Gene | 80829 |
Alt Symbol | DMS-8, DSM-8, FKSG11, PZF, ZFP-91, ZNF757 |
Species | Human |
Gene Type | protein-coding |
Description | ZFP91 zinc finger protein |
Other Description | E3 ubiquitin-protein ligase ZFP91|drug resistance-associated sequence in melanoma 8|penta zinc finger protein|zinc finger protein 757|zinc finger protein 91 homolog|zinc finger protein homologous to Zfp91 in mouse |
Swissprots | Q96JP4 A8MSG7 Q96JP5 Q96QA3 Q86V47 A6NHC4 |
Accessions | EAW73811 EAW73813 EAW73816 EAW73817 EAW73818 Q96JP5 AB056107 BAB63373 AF305825 AAK55528 AF310246 AAL09963 AI687439 AJ270692 AK025502 AK295700 BAG58548 BC051743 AAH51743 BP219969 NM_001197051 NP_001183980 NM_053023 NP_444251 |
Function | Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12738986}. |
Tissue Specificity | Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific. |
ZFP91 CRISPR/Cas9 KO Plasmid (h) - sc-416309 from Santa Cruz Biotechnology
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ZFP91 HDR Plasmid (h) - sc-416309-HDR from Santa Cruz Biotechnology
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ZFP91 Double Nickase Plasmid (h) - sc-416309-NIC from Santa Cruz Biotechnology
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ZFP91 Double Nickase Plasmid (h2) - sc-416309-NIC-2 from Santa Cruz Biotechnology
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ZFP91 CRISPR Activation Plasmid (h) - sc-416309-ACT from Santa Cruz Biotechnology
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ZFP91 CRISPR Activation Plasmid (h2) - sc-416309-ACT-2 from Santa Cruz Biotechnology
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ZFP91 Lentiviral Activation Particles (h) - sc-416309-LAC from Santa Cruz Biotechnology
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ZFP91 Lentiviral Activation Particles (h2) - sc-416309-LAC-2 from Santa Cruz Biotechnology
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ZFP91 siRNA (h) - sc-106726 from Santa Cruz Biotechnology
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ZFP91 shRNA Plasmid (h) - sc-106726-SH from Santa Cruz Biotechnology
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ZFP91 shRNA (h) Lentiviral Particles - sc-106726-V from Santa Cruz Biotechnology
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ZFP91 RNAi - H00080829-R01 from Novus Biologicals
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MISSION® esiRNA - EHU096461 from Sigma-Aldrich
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MISSION® esiRNA - EHU093431 from Sigma-Aldrich
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MISSION® esiRNA - EHU104291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23192 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13969 from Sigma-Aldrich
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ZFP91 siRNA (Human) - CRJ2925 from Cohesion Biosciences
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ZFP91 RNAi - H00080829-R02 from Novus Biologicals
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ZFP91 - MBS8231322 from MyBioSource
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shRNA set against Human ZFP91 (NM_053023.4) - SHH452200 from Creative biogene
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Human ZFP91 siRNA - orb273426 from Biorbyt
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ZFP91 shRNA Plasmid (Human) - CHJ2925 from Cohesion Biosciences
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ZFP91 miRNA 3'UTR clone - MiUTR4H-TG10065 from Creative biogene
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