Gene Symbol | AUH |
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Entrez Gene | 549 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | AU RNA binding protein/enoyl-CoA hydratase |
Other Description | 3-methylglutaconyl-CoA hydratase|AU RNA-binding protein/enoyl-Coenzyme A hydratase|AU-binding protein/Enoyl-CoA hydratase|AU-specific RNA-binding enoyl-CoA hydratase|methylglutaconyl-CoA hydratase, mitochondrial |
Swissprots | Q8WUE4 B1ALV7 B1ALV8 Q13825 |
Accessions | EAW62794 EAW62795 Q13825 AK124142 AK302453 BAG63748 AM393420 CAL38298 AV751432 BC020722 AAH20722 BG706374 BI667104 DA724873 DQ892036 ABM82962 DQ895227 ABM86153 X79888 CAA56260 XM_005252066 XP_005252123 XM_005252067 XP_005252124 XM_005252068 XP_005252125 XM_005252069 XP_005252126 XM_005252072 XP_005252129 XM_005252073 XP_005252130 XM_006717150 XP_006717213 XM_011518800 XP_011517102 XM_011518801 XP_011517103 XM_011518802 XP_011517104 XM_011518803 XP_011517105 XM_011518804 XP_011517106 XR_929814 NM_001306190 NP_001293119 NM_001698 NP_001689 |
Function | Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs. {ECO:0000269|PubMed:11738050, ECO:0000269|PubMed:12434311, ECO:0000269|PubMed:12655555, ECO:0000269|PubMed:7892223}. |
Subcellular Location | Mitochondrion {ECO:0000250}. |
Top Pathways | Valine, leucine and isoleucine degradation |
AUH CRISPR/Cas9 KO Plasmid (h) - sc-410698 from Santa Cruz Biotechnology
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AUH HDR Plasmid (h) - sc-410698-HDR from Santa Cruz Biotechnology
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AUH Double Nickase Plasmid (h) - sc-410698-NIC from Santa Cruz Biotechnology
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AUH Double Nickase Plasmid (h2) - sc-410698-NIC-2 from Santa Cruz Biotechnology
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AUH CRISPR Activation Plasmid (h) - sc-410698-ACT from Santa Cruz Biotechnology
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AUH CRISPR Activation Plasmid (h2) - sc-410698-ACT-2 from Santa Cruz Biotechnology
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AUH Lentiviral Activation Particles (h) - sc-410698-LAC from Santa Cruz Biotechnology
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AUH Lentiviral Activation Particles (h2) - sc-410698-LAC-2 from Santa Cruz Biotechnology
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AUH siRNA (h) - sc-72593 from Santa Cruz Biotechnology
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AUH shRNA Plasmid (h) - sc-72593-SH from Santa Cruz Biotechnology
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AUH shRNA (h) Lentiviral Particles - sc-72593-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU096001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3770 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3770 from Sigma-Aldrich
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AUH siRNA (Human) - CRH0378 from Cohesion Biosciences
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AUH - MBS8227854 from MyBioSource
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shRNA set against Human AUH (NM_001698.2) - SHH243698 from Creative biogene
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shRNA set against Human AUH(NM_001698.2) - SHG086033 from Creative biogene
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AUH shRNA Plasmid (Human) - CHH0378 from Cohesion Biosciences
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AUH miRNA 3'UTR clone - MiUTR1H-00744 from Creative biogene
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