Gene Symbol | RRM1 |
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Entrez Gene | 6240 |
Alt Symbol | R1, RIR1, RR1 |
Species | Human |
Gene Type | protein-coding |
Description | ribonucleotide reductase M1 |
Other Description | ribonucleoside-diphosphate reductase large subunit|ribonucleoside-diphosphate reductase subunit M1|ribonucleotide reductase M1 polypeptide|ribonucleotide reductase, R1 subunit |
Swissprots | P23921 Q9UNN2 |
Accessions | AAD37491 EAX02583 P23921 AK222786 BAD96506 AK297988 BAG60296 AK299629 BAG61557 AK301891 BAG63322 AK301922 BAG63343 AK303394 BAG64450 AK307950 AK311593 BC006498 AAH06498 BP229960 BQ775841 DQ893028 ABM83954 DQ896272 ABM87271 X59543 CAA42118 X59617 CAA42180 XM_011520277 XP_011518579 XM_011520278 XP_011518580 XM_011520279 XP_011518581 NM_001033 NP_001024 |
Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
Subcellular Location | Cytoplasm. |
Top Pathways | Purine metabolism, Glutathione metabolism, Pyrimidine metabolism |
R1 CRISPR/Cas9 KO Plasmid (h) - sc-401712 from Santa Cruz Biotechnology
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R1 HDR Plasmid (h) - sc-401712-HDR from Santa Cruz Biotechnology
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R1 Double Nickase Plasmid (h) - sc-401712-NIC from Santa Cruz Biotechnology
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R1 Double Nickase Plasmid (h2) - sc-401712-NIC-2 from Santa Cruz Biotechnology
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R1 CRISPR Activation Plasmid (h) - sc-401712-ACT from Santa Cruz Biotechnology
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R1 CRISPR Activation Plasmid (h2) - sc-401712-ACT-2 from Santa Cruz Biotechnology
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R1 Lentiviral Activation Particles (h) - sc-401712-LAC from Santa Cruz Biotechnology
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R1 Lentiviral Activation Particles (h2) - sc-401712-LAC-2 from Santa Cruz Biotechnology
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R1 siRNA (h) - sc-37640 from Santa Cruz Biotechnology
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R1 shRNA Plasmid (h) - sc-37640-SH from Santa Cruz Biotechnology
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R1 shRNA (h) Lentiviral Particles - sc-37640-V from Santa Cruz Biotechnology
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RRM1 RNAi - H00006240-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18685 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04380 from Sigma-Aldrich
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RRM1 siRNA (Human) - CRH4203 from Cohesion Biosciences
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RRM1 - MBS8220134 from MyBioSource
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shRNA set against Human RRM1 (NM_001033.3) - SHH399952 from Creative biogene
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Human RRM1 siRNA - orb264705 from Biorbyt
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RRM1 shRNA Plasmid (Human) - CHH4203 from Cohesion Biosciences
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RRM1 miRNA 3'UTR clone - MiUTR1H-09045 from Creative biogene
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