RRM1

Gene Symbol RRM1
Entrez Gene 6240
Alt Symbol R1, RIR1, RR1
Species Human
Gene Type protein-coding
Description ribonucleotide reductase M1
Other Description ribonucleoside-diphosphate reductase large subunit|ribonucleoside-diphosphate reductase subunit M1|ribonucleotide reductase M1 polypeptide|ribonucleotide reductase, R1 subunit
Swissprots P23921 Q9UNN2
Accessions AAD37491 EAX02583 P23921 AK222786 BAD96506 AK297988 BAG60296 AK299629 BAG61557 AK301891 BAG63322 AK301922 BAG63343 AK303394 BAG64450 AK307950 AK311593 BC006498 AAH06498 BP229960 BQ775841 DQ893028 ABM83954 DQ896272 ABM87271 X59543 CAA42118 X59617 CAA42180 XM_011520277 XP_011518579 XM_011520278 XP_011518580 XM_011520279 XP_011518581 NM_001033 NP_001024
Function Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Subcellular Location Cytoplasm.
Top Pathways Purine metabolism, Glutathione metabolism, Pyrimidine metabolism

RRM1 (D12F12) XP ® Rabbit mAb - 8637 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12F12
Western blot analysis of extracts from various cell lines using RRM1 (D12F12) XP ® Rabbit mAb (upper) and β-Actin Antibody #4967 (lower).

RRM1 Antibody - 3388 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using RRM1 Antibody.

R1 (A-10) - sc-377415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
R1 (A-10): sc-377415. Western blot analysis of R1 expression in non-transfected: sc-117752 (A) and human R1 transfected: sc-158910 (B) 293T whole cell lysates.

R1 (H-300) - sc-22786 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
R1 (H-300): sc-22786. Immuno?fluorescence staining of methanol-fixed HeLa cells showing cytoplasmic local?ization.

R1 (E-7) - sc-377426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
R1 (E-7): sc-377426. Western blot analysis of R1 expression in non-transfected: sc-117752 (A) and human R1 transfected: sc-158910 (B) 293T whole cell lysates.

R1 (T-16) - sc-11733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
R1 (T-16): sc-11733. Western blot analysis of R1 expression in HeLa whole cell lysate.

R1 (Y-16) - sc-11731 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
R1 (Y-16): sc-11731. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic localization.

Anti-RRM1 antibody - ab81085 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab81085, at 1/100 dilution, staining RRM1 in Human Placenta by Immunohistochemistry using formalin-fixed paraffin-embedded tissue.

Anti-RRM1 antibody - ab180811 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab180811. Blue DAPI for nuclear staining.

Anti-RRM1 antibody - ab125713 from Abcam

Prices $376.00
Sizes 10 µl
Host Rabbit
Clonality Polyclonal
Anti-RRM1 antibody (ab125713) at 1/2000 dilution + 293T lysate at 30 µg

Anti-RRM1 antibody - ab179913 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RRM1 antibody (ab179913) at 1/1000 dilution + S. pombe crude extractSecondaryanti-rabbit IgG conjugated with HRP at 1/10000 dilutiondeveloped using the ECL technique

Anti-RRM1 antibody - ab57652 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57652 RRM1 antibody at 1ug/ml.

Anti-RRM1 antibody [5G5] - ab157250 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G5
All lanes : Anti-RRM1 antibody [5G5] (ab157250) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY RRM1 Lysates/proteins at 5 µg per lane.

Anti-RRM1 antibody [EPR8482] - ab133690 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8482
Immunohistochemical analysis of paraffin-embedded Human placenta tissue labelling RRM1 with ab133690 at 1/250 dilution.

Anti-RRM1 antibody [EPR8483] - ab137114 from Abcam

Prices $99.00, $385.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8483
All lanes : Anti-RRM1 antibody [EPR8483] (ab137114) at 1/10000 dilutionLane 1 : HT29 cell lysateLane 2 : A549 cell lysateLane 3 : MCF7 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP-labeled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-RRM1 antibody [EPR8483] (Alexa Fluor® 488) - ab197487 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8483
Overlay histogram showing HeLa cells stained with ab197487 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab197487, 1/500 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.This antibody gave a positive signal in HeLa fixed with 4% formaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-RRM1 antibody, prediluted - ab80924 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human placenta tissue, using 1/100 ab80924.

Anti-RRM1 antibody [SP167] - ab135383 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP167
Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody ab135383 (1/400) in HeLa cells (green) compared to negative control of rabbit IgG (blue).

Anti-RRM1 antibody - N-terminal - ab156249 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RRM1 antibody - N-terminal (ab156249) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-R1 / RRM1 Antibody (Internal, clone SP167) - LS-C210398 from LifeSpan Bioscience

Prices $530.00
Sizes 500 µl
Host Rabbit
Clonality Monoclonal
Clone SP167
Immunohistochemistry of Human Lung Squamous Cell Carcinoma stained with anti-RRM-1 antibody

Anti-R1 / RRM1 Antibody (aa71-100, Azide-free, HRP) - LS-C268613 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-R1 / RRM1 Antibody (C-Terminus) - LS-C210505 from LifeSpan Bioscience

Prices $360.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Placenta stained with anti-RRMI antibody

Anti-R1 / RRM1 Antibody - LS-C192405 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of RRM1 pAb in extracts from A549 and SH-SY5Y cells.

Anti-R1 / RRM1 Antibody (aa71-100, PE) - LS-C268614 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-R1 / RRM1 Antibody - LS-C155176 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Colon ca, using RRM1 antibody at 1:500 dilution.
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