Gene Symbol |
UPK3A
|
Entrez Gene |
7380
|
Alt Symbol |
UP3A, UPIII, UPIIIA, UPK3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
uroplakin 3A
|
Other Description |
uroplakin 3|uroplakin III|uroplakin-3a
|
Swissprots |
B0QY25 Q5TII6 O75631 Q32N05 O60261
|
Accessions |
EAW73377 O75631 AB010116 BAA25678 AB010637 BAA31460 AF085808 AAC34888 BC069544 AAH69544 BC108900 AAI08901 BM681088 BM727658 CR456608 CAG30494 CU013204 CAK54635 CU013492 CAK54934 XM_011530364 XP_011528666 XM_011530365 XP_011528667 NM_001167574 NP_001161046 NM_006953 NP_008884
|
Function |
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.
|
Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
|
Tissue Specificity |
Expressed in ureter. {ECO:0000269|PubMed:9846985}.
|