Gene Symbol | UPK3A |
---|---|
Entrez Gene | 7380 |
Alt Symbol | UP3A, UPIII, UPIIIA, UPK3 |
Species | Human |
Gene Type | protein-coding |
Description | uroplakin 3A |
Other Description | uroplakin 3|uroplakin III|uroplakin-3a |
Swissprots | B0QY25 Q5TII6 O75631 Q32N05 O60261 |
Accessions | EAW73377 O75631 AB010116 BAA25678 AB010637 BAA31460 AF085808 AAC34888 BC069544 AAH69544 BC108900 AAI08901 BM681088 BM727658 CR456608 CAG30494 CU013204 CAK54635 CU013492 CAK54934 XM_011530364 XP_011528666 XM_011530365 XP_011528667 NM_001167574 NP_001161046 NM_006953 NP_008884 |
Function | Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}. |
Tissue Specificity | Expressed in ureter. {ECO:0000269|PubMed:9846985}. |
UPIIIa CRISPR/Cas9 KO Plasmid (h) - sc-401796 from Santa Cruz Biotechnology
|
||||||||
UPIIIa HDR Plasmid (h) - sc-401796-HDR from Santa Cruz Biotechnology
|
||||||||
UPIIIa Double Nickase Plasmid (h) - sc-401796-NIC from Santa Cruz Biotechnology
|
||||||||
UPIIIa Double Nickase Plasmid (h2) - sc-401796-NIC-2 from Santa Cruz Biotechnology
|
||||||||
UPIIIa CRISPR Activation Plasmid (h) - sc-401796-ACT from Santa Cruz Biotechnology
|
||||||||
UPIIIa CRISPR Activation Plasmid (h2) - sc-401796-ACT-2 from Santa Cruz Biotechnology
|
||||||||
UPIIIa Lentiviral Activation Particles (h) - sc-401796-LAC from Santa Cruz Biotechnology
|
||||||||
UPIIIa Lentiviral Activation Particles (h2) - sc-401796-LAC-2 from Santa Cruz Biotechnology
|
||||||||
UPIII siRNA (h) - sc-41096 from Santa Cruz Biotechnology
|
||||||||
UPIII shRNA Plasmid (h) - sc-41096-SH from Santa Cruz Biotechnology
|
||||||||
UPIII shRNA (h) Lentiviral Particles - sc-41096-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22523 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22523 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR00275 from Sigma-Aldrich
|
||||||||
UPK3A siRNA (Human) - CRH5049 from Cohesion Biosciences
|
||||||||
UPK3A - MBS8220405 from MyBioSource
|
||||||||
UPIIIa CRISPR/Cas9 KO Plasmid (h2) - sc-401796-KO-2 from Santa Cruz Biotechnology
|
||||||||
UPIIIa HDR Plasmid (h2) - sc-401796-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human UPK3A (NM_006953.3) - SHH440812 from Creative biogene
|
||||||||
Human UPK3A siRNA - orb265551 from Biorbyt
|
||||||||
UPK3A shRNA Plasmid (Human) - CHH5049 from Cohesion Biosciences
|
||||||||
UPK3A miRNA 3'UTR clone - MiUTR4H-TG12739 from Creative biogene
|