FHIT

Gene Symbol FHIT
Entrez Gene 2272
Alt Symbol AP3Aase, FRA3B
Species Human
Gene Type protein-coding
Description fragile histidine triad
Other Description AP3A hydrolase|bis(5'-adenosyl)-triphosphatase|diadenosine 5',5'''-P1,P3-triphosphate hydrolase|dinucleosidetriphosphatase|tumor suppressor protein
Swissprots A2IAT0 P49789 A8K1A9 Q6IU12 A2IAS9 Q45QG9 A2IAT6
Accessions AAB52539 AAB53793 AAB84098 AAT37530 ABD93870 ABD93871 ABG02271 ABG02272 ABG02273 ABG02274 ABG02275 ABG81420 ABI15739 ABI15740 ABI15741 ABI15742 ABM65879 ABM66086 ABM66087 ABM66088 ABM66089 ABM66090 ABM66091 ABM66092 ABM66093 CAY55966 EAW65393 EAW65394 P49789 AK127931 AK289824 BAF82513 BC032336 AAH32336 BC057223 DA239143 DQ120721 AAZ23623 DQ891575 ABM82501 DQ894769 ABM85695 KJ534835 AHW56475 U46922 AAA99013 XM_011533481 XP_011531783 XM_011533482 XP_011531784 XM_011533483 XP_011531785 XM_011533484 XP_011531786 XM_011533485 XP_011531787 XM_011533486 XP_011531788 NM_001166243 NP_001159715 NM_002012 NP_002003
Function Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. {ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:
Subcellular Location Cytoplasm. Mitochondrion. Nucleus.
Tissue Specificity Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
Top Pathways Small cell lung cancer, Non-small cell lung cancer, Purine metabolism

Fhit CRISPR/Cas9 KO Plasmid (h) - sc-404220 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit HDR Plasmid (h) - sc-404220-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit Double Nickase Plasmid (h) - sc-404220-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit Double Nickase Plasmid (h2) - sc-404220-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit CRISPR Activation Plasmid (h) - sc-404220-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit CRISPR Activation Plasmid (h2) - sc-404220-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit Lentiviral Activation Particles (h) - sc-404220-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit Lentiviral Activation Particles (h2) - sc-404220-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fhit siRNA (h) - sc-106872 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fhit shRNA Plasmid (h) - sc-106872-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fhit shRNA (h) Lentiviral Particles - sc-106872-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FHIT RNAi - H00002272-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU055691 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8681 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8681 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02078 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02078

FHIT siRNA (Human) - CRH1589 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FHIT - MBS8213395 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human FHIT siRNA - orb262091 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FHIT shRNA Plasmid (Human) - CHH1589 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FHIT miRNA 3'UTR clone - MiUTR3H-03915 from Creative biogene

Species Reactivities Human

FHIT miRNA 3'UTR clone - MiUTR3H-03916 from Creative biogene

Species Reactivities Human
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