| Gene Symbol |
HIST1H2BO
|
| Entrez Gene |
8348
|
| Alt Symbol |
H2B.2, H2B/n, H2BFN, dJ193B12.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2bo
|
| Other Description |
H2B histone family, member N|histone 1, H2bo|histone H2B type 1-O|histone H2B.2|histone H2B.n
|
| Swissprots |
Q8TCV6 P23527 Q3KPI7
|
| Accessions |
AAN06698 CAA40416 EAX03124 P23527 BC106720 AAI06721 BX647290 EU446972 ABZ92501 NM_003527 NP_003518
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|